Antioxidative, antimutagenic, and cytotoxic activities of ethanol extracts from Cornus officianalis

Yeon Hoe Jeon, Mi Hyun Kim, Mee Ra Kim

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The antioxidative, antimutagenic and cytotoxic activities of ethanol extract from Cornus officianalis have been studied. The antioxidant activity of the ethanol extract was measured by 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The inhibition effects on the mutagenicity in Salmonella Typhimurium TA100 were evaluated by Ames test and cancer cell inhibitory effects in Hep3B cell and HeLa cell were tested by MTT assay. Cornus officianalis had an important free radical-scavenging activity towards the DPPH radical. At a concentration of 500 ppm, the DPPH radical-scavenging activity of Cornus officianalis was similar to that of L-ascorbic acid. None of the extracts produced a mutagenic effect on S. Typhimurium TA100. The ethanol extract from Cornus officianalis showed about 77% of inhibition at 500 ppm on the mutagenicity induced by 4-nitroquinoline-1-oxide. The extract from Cornus officianalis showed strong cytotoxicity against Hep3B and HeLa cells, with inhibition of 83 and 78% at a dose of 700 μg/plate, respectively. Moreover, the ethanol extracts had 34.33 mg H.E/g of polyphenols and 5.67 mg Q.E/g of flavonoids, respectively. Therefore, the present study showed antioxidative, antimutagenic and anticancer potential of the ethanol extract from Cornus officianalis.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of the Korean Society of Food Science and Nutrition
Volume37
Issue number1
DOIs
StatePublished - 2008

Keywords

  • Ames test
  • Cornus officianalis
  • DPPH
  • MTT assay

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