Antiplatelet effects of acidamides isolated from the fruits of Piper longum L.

B. S. Park; D. J. Son; Y. H. Park; T. W. Kim; S. E. Lee

doi:10.1016/j.phymed.2007.06.011

Antiplatelet effects of acidamides isolated from the fruits of Piper longum L.

B. S. Park, D. J. Son, Y. H. Park, T. W. Kim, S. E. Lee

School of Applied Bioscience

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

The inhibitory effects of four acidamides, piperine, pipernonaline, piperoctadecalidine, and piperlongumine, isolated from the fruits of Piper longum L. on washed rabbit platelet aggregation were examined. All of the four tested acidamides showed dose-dependent inhibitory activities on washed rabbit platelet aggregation induced by collagen, arachidonic acid (AA), and platelet-activating factor (PAF), except for that induced by thrombin. Piperlongumine, in particular, showed stronger inhibitory effects than other acidamides to rabbit platelet aggregation induced by collagen, AA and PAF.

Original language	English
Pages (from-to)	853-855
Number of pages	3
Journal	Phytomedicine
Volume	14
Issue number	12
DOIs	https://doi.org/10.1016/j.phymed.2007.06.011
State	Published - 4 Dec 2007

Keywords

Antiplatelet activity
Piper longum L.
Piperlongumine

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10.1016/j.phymed.2007.06.011

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title = "Antiplatelet effects of acidamides isolated from the fruits of Piper longum L.",

abstract = "The inhibitory effects of four acidamides, piperine, pipernonaline, piperoctadecalidine, and piperlongumine, isolated from the fruits of Piper longum L. on washed rabbit platelet aggregation were examined. All of the four tested acidamides showed dose-dependent inhibitory activities on washed rabbit platelet aggregation induced by collagen, arachidonic acid (AA), and platelet-activating factor (PAF), except for that induced by thrombin. Piperlongumine, in particular, showed stronger inhibitory effects than other acidamides to rabbit platelet aggregation induced by collagen, AA and PAF.",

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AU - Park, B. S.

AU - Son, D. J.

AU - Park, Y. H.

AU - Kim, T. W.

AU - Lee, S. E.

PY - 2007/12/4

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N2 - The inhibitory effects of four acidamides, piperine, pipernonaline, piperoctadecalidine, and piperlongumine, isolated from the fruits of Piper longum L. on washed rabbit platelet aggregation were examined. All of the four tested acidamides showed dose-dependent inhibitory activities on washed rabbit platelet aggregation induced by collagen, arachidonic acid (AA), and platelet-activating factor (PAF), except for that induced by thrombin. Piperlongumine, in particular, showed stronger inhibitory effects than other acidamides to rabbit platelet aggregation induced by collagen, AA and PAF.

AB - The inhibitory effects of four acidamides, piperine, pipernonaline, piperoctadecalidine, and piperlongumine, isolated from the fruits of Piper longum L. on washed rabbit platelet aggregation were examined. All of the four tested acidamides showed dose-dependent inhibitory activities on washed rabbit platelet aggregation induced by collagen, arachidonic acid (AA), and platelet-activating factor (PAF), except for that induced by thrombin. Piperlongumine, in particular, showed stronger inhibitory effects than other acidamides to rabbit platelet aggregation induced by collagen, AA and PAF.

KW - Antiplatelet activity

KW - Piper longum L.

KW - Piperlongumine

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Antiplatelet effects of acidamides isolated from the fruits of Piper longum L.

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Keywords

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