TY - JOUR
T1 - Application of Monodirectional Janus Patch to Oromucosal Delivery System
AU - You, Jae Bem
AU - Choi, Ah Young
AU - Baek, Jieung
AU - Oh, Myung Seok
AU - Im, Sung Gap
AU - Lee, Kyung Eun
AU - Gwak, Hye Sun
N1 - Publisher Copyright:
& Co. KGaA, Weinheim.
PY - 2015/10/28
Y1 - 2015/10/28
N2 - Drug delivery through mucosae has received huge research attention owing to its advantageous characteristics such as accurate dose control and the avoidance of premature metabolism of vulnerable drugs by oral administration. However, body fluid in mucosae may dissolve the drug, releasing it to unwanted directions. Here, a Janus drug delivery patch with monodirectional diffusion property is devised to deliver drugs efficiently and to overcome the issue of unwanted drug release. A polyester fabric is coated with a hydrophobic polymer, poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-heptadecafluorodecyl methacrylate), via initiated chemical vapor deposition. Subsequently, hydrophilicity is rendered selectively on one surface by base-catalyzed hydrolysis to obtain a Janus substrate with both hydrophobic and hydrophilic surfaces. The hydrophilic surface of the Janus substrate is further coated with resveratrol-loaded hydrogel to produce a Janus drug delivery patch. The fabricated patch efficiently blocks fluid penetration from one side to the other in mucous environment. Delivery of resveratrol through hairless mouse skin and reconstructed human mucosae using Janus patch shows higher permeation flux compared to bare control patch. The Janus drug delivery patch shown in this study can be a useful tool for efficient transmucosal delivery of various kinds of drugs.
AB - Drug delivery through mucosae has received huge research attention owing to its advantageous characteristics such as accurate dose control and the avoidance of premature metabolism of vulnerable drugs by oral administration. However, body fluid in mucosae may dissolve the drug, releasing it to unwanted directions. Here, a Janus drug delivery patch with monodirectional diffusion property is devised to deliver drugs efficiently and to overcome the issue of unwanted drug release. A polyester fabric is coated with a hydrophobic polymer, poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-heptadecafluorodecyl methacrylate), via initiated chemical vapor deposition. Subsequently, hydrophilicity is rendered selectively on one surface by base-catalyzed hydrolysis to obtain a Janus substrate with both hydrophobic and hydrophilic surfaces. The hydrophilic surface of the Janus substrate is further coated with resveratrol-loaded hydrogel to produce a Janus drug delivery patch. The fabricated patch efficiently blocks fluid penetration from one side to the other in mucous environment. Delivery of resveratrol through hairless mouse skin and reconstructed human mucosae using Janus patch shows higher permeation flux compared to bare control patch. The Janus drug delivery patch shown in this study can be a useful tool for efficient transmucosal delivery of various kinds of drugs.
KW - Drug delivery
KW - Initiated chemical vapor deposition (iCVD)
KW - Janus patch
KW - Monodirectional
KW - Oromucosa
UR - http://www.scopus.com/inward/record.url?scp=84945443488&partnerID=8YFLogxK
U2 - 10.1002/adhm.201500416
DO - 10.1002/adhm.201500416
M3 - Article
C2 - 26346613
AN - SCOPUS:84945443488
SN - 2192-2640
VL - 4
SP - 2229
EP - 2236
JO - Advanced healthcare materials
JF - Advanced healthcare materials
IS - 15
ER -