Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

Asami Tsukiashi; Kil Sik Min; Hikaru Kitayama; Hiroaki Terasawa; Sosuke Yoshinaga; Mitsuhiro Takeda; Leonard F. Lindoy; Shinya Hayami

doi:10.1038/s41598-018-33362-6

Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

Asami Tsukiashi, Kil Sik Min, Hikaru Kitayama, Hiroaki Terasawa, Sosuke Yoshinaga, Mitsuhiro Takeda, Leonard F. Lindoy, Shinya Hayami

Department of Chemical Science Education

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)_3-3×(NH₂trz)_3×](BF₄)₂ (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.

Original language	English
Article number	14911
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-33362-6
State	Published - 1 Dec 2018

Access to Document

10.1038/s41598-018-33362-6

Cite this

@article{82e74b95a71c4f2297d1e71e6732df64,

title = "Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents",

abstract = "Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)3-3×(NH2trz)3×](BF4)2 (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.",

author = "Asami Tsukiashi and Min, {Kil Sik} and Hikaru Kitayama and Hiroaki Terasawa and Sosuke Yoshinaga and Mitsuhiro Takeda and Lindoy, {Leonard F.} and Shinya Hayami",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",

year = "2018",

month = dec,

day = "1",

doi = "10.1038/s41598-018-33362-6",

language = "English",

volume = "8",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

AU - Tsukiashi, Asami

AU - Min, Kil Sik

AU - Kitayama, Hikaru

AU - Terasawa, Hiroaki

AU - Yoshinaga, Sosuke

AU - Takeda, Mitsuhiro

AU - Lindoy, Leonard F.

AU - Hayami, Shinya

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)3-3×(NH2trz)3×](BF4)2 (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.

AB - Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)3-3×(NH2trz)3×](BF4)2 (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.

UR - http://www.scopus.com/inward/record.url?scp=85054603089&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-33362-6

DO - 10.1038/s41598-018-33362-6

M3 - Article

C2 - 30297794

AN - SCOPUS:85054603089

SN - 2045-2322

VL - 8

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 14911

ER -

Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

Abstract

Access to Document

Other files and links

Fingerprint

Cite this