Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

Asami Tsukiashi; Kil Sik Min; Hikaru Kitayama; Hiroaki Terasawa; Sosuke Yoshinaga; Mitsuhiro Takeda; Leonard F. Lindoy; Shinya Hayami

doi:10.1038/s41598-018-33362-6

Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

Asami Tsukiashi
, Kil Sik Min
, Hikaru Kitayama
, Hiroaki Terasawa
, Sosuke Yoshinaga
, Mitsuhiro Takeda
, Leonard F. Lindoy
, Shinya Hayami

Department of Chemical Science Education

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)_3-3×(NH₂trz)_3×](BF₄)₂ (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.

Original language	English
Article number	14911
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-33362-6
State	Published - 1 Dec 2018

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title = "Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents",

abstract = "Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)3-3×(NH2trz)3×](BF4)2 (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.",

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AU - Tsukiashi, Asami

AU - Min, Kil Sik

AU - Kitayama, Hikaru

AU - Terasawa, Hiroaki

AU - Yoshinaga, Sosuke

AU - Takeda, Mitsuhiro

AU - Lindoy, Leonard F.

AU - Hayami, Shinya

PY - 2018/12/1

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N2 - Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)3-3×(NH2trz)3×](BF4)2 (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.

AB - Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)3-3×(NH2trz)3×](BF4)2 (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280–330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.

UR - https://www.scopus.com/pages/publications/85054603089

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VL - 8

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 14911

ER -

Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

Abstract

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