Aquaporin-5 in breast cancer

Malte Bystrup; Frédéric H. Login; Sarannya Edamana; Signe Borgquist; Trine Tramm; Tae Hwan Kwon; Lene N. Nejsum

doi:10.1111/apm.13212

Aquaporin-5 in breast cancer

Malte Bystrup, Frédéric H. Login, Sarannya Edamana, Signe Borgquist, Trine Tramm, Tae Hwan Kwon, Lene N. Nejsum

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands. AQP5 is ectopically overexpressed in breast cancer, where expression is associated with lymph node metastasis and poor prognosis. Besides the role in water transport, AQP5 has been found to play a role in cancer metastasis, migration, and proliferation. AQP5 has also been shown to be involved in the dysregulation of epithelial cell–cell adhesion; frequently observed in cancers. Insight into the underlying molecular mechanisms of how AQP5 contributes to cancer development and progression is essential for potentially implementing AQP5 as a prognostic biomarker and to develop targeted intervention strategies for the treatment of breast cancer patients.

Original language	English
Pages (from-to)	253-260
Number of pages	8
Journal	APMIS
Volume	130
Issue number	5
DOIs	https://doi.org/10.1111/apm.13212
State	Published - May 2022

Keywords

aquaporin-5
biomarker
breast cancer
carcinoma
migration
proliferation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/apm.13212

Cite this

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title = "Aquaporin-5 in breast cancer",

abstract = "The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands. AQP5 is ectopically overexpressed in breast cancer, where expression is associated with lymph node metastasis and poor prognosis. Besides the role in water transport, AQP5 has been found to play a role in cancer metastasis, migration, and proliferation. AQP5 has also been shown to be involved in the dysregulation of epithelial cell–cell adhesion; frequently observed in cancers. Insight into the underlying molecular mechanisms of how AQP5 contributes to cancer development and progression is essential for potentially implementing AQP5 as a prognostic biomarker and to develop targeted intervention strategies for the treatment of breast cancer patients.",

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doi = "10.1111/apm.13212",

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AU - Bystrup, Malte

AU - Login, Frédéric H.

AU - Edamana, Sarannya

AU - Borgquist, Signe

AU - Tramm, Trine

AU - Kwon, Tae Hwan

AU - Nejsum, Lene N.

PY - 2022/5

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AB - The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands. AQP5 is ectopically overexpressed in breast cancer, where expression is associated with lymph node metastasis and poor prognosis. Besides the role in water transport, AQP5 has been found to play a role in cancer metastasis, migration, and proliferation. AQP5 has also been shown to be involved in the dysregulation of epithelial cell–cell adhesion; frequently observed in cancers. Insight into the underlying molecular mechanisms of how AQP5 contributes to cancer development and progression is essential for potentially implementing AQP5 as a prognostic biomarker and to develop targeted intervention strategies for the treatment of breast cancer patients.

KW - aquaporin-5

KW - biomarker

KW - breast cancer

KW - carcinoma

KW - migration

KW - proliferation

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DO - 10.1111/apm.13212

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VL - 130

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JO - APMIS

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Aquaporin-5 in breast cancer

Abstract

Keywords

UN SDGs

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