Aquaporins in the spinal cord

Michal K. Oklinski; Mariusz T. Skowronski; Agnieszka Skowronska; Michael Rützler; Kirsten Nørgaard; John D. Nieland; Tae Hwan Kwon; Søren Nielsen

doi:10.3390/ijms17122050

Aquaporins in the spinal cord

Michal K. Oklinski, Mariusz T. Skowronski, Agnieszka Skowronska, Michael Rützler, Kirsten Nørgaard, John D. Nieland, Tae Hwan Kwon, Søren Nielsen

Department of Medicine

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

Aquaporins (AQPs) are water channel proteins robustly expressed in the central nervous system (CNS). A number of previous studies described the cellular expression sites and investigated their major roles and function in the brain and spinal cord. Among thirteen different mammalian AQPs, AQP1 and AQP4 have been mainly studied in the CNS and evidence has been presented that they play important roles in the pathogenesis of CNS injury, edema and multiple diseases such as multiple sclerosis, neuromyelitis optica spectrum disorders, amyotrophic lateral sclerosis, glioblastoma multiforme, Alzheimer’s disease and Parkinson’s disease. The objective of this review is to highlight the current knowledge about AQPs in the spinal cord and their proposed roles in pathophysiology and pathogenesis related to spinal cord lesions and injury.

Original language	English
Article number	2050
Journal	International Journal of Molecular Sciences
Volume	17
Issue number	12
DOIs	https://doi.org/10.3390/ijms17122050
State	Published - 7 Dec 2016

Keywords

Aquaporin
Astrocytes
Central nervous system
Endothelial cells
Neurons
Peripheral nerve
Spinal cord

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10.3390/ijms17122050

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title = "Aquaporins in the spinal cord",

abstract = "Aquaporins (AQPs) are water channel proteins robustly expressed in the central nervous system (CNS). A number of previous studies described the cellular expression sites and investigated their major roles and function in the brain and spinal cord. Among thirteen different mammalian AQPs, AQP1 and AQP4 have been mainly studied in the CNS and evidence has been presented that they play important roles in the pathogenesis of CNS injury, edema and multiple diseases such as multiple sclerosis, neuromyelitis optica spectrum disorders, amyotrophic lateral sclerosis, glioblastoma multiforme, Alzheimer{\textquoteright}s disease and Parkinson{\textquoteright}s disease. The objective of this review is to highlight the current knowledge about AQPs in the spinal cord and their proposed roles in pathophysiology and pathogenesis related to spinal cord lesions and injury.",

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AU - Oklinski, Michal K.

AU - Skowronski, Mariusz T.

AU - Skowronska, Agnieszka

AU - Rützler, Michael

AU - Nørgaard, Kirsten

AU - Nieland, John D.

AU - Kwon, Tae Hwan

AU - Nielsen, Søren

PY - 2016/12/7

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N2 - Aquaporins (AQPs) are water channel proteins robustly expressed in the central nervous system (CNS). A number of previous studies described the cellular expression sites and investigated their major roles and function in the brain and spinal cord. Among thirteen different mammalian AQPs, AQP1 and AQP4 have been mainly studied in the CNS and evidence has been presented that they play important roles in the pathogenesis of CNS injury, edema and multiple diseases such as multiple sclerosis, neuromyelitis optica spectrum disorders, amyotrophic lateral sclerosis, glioblastoma multiforme, Alzheimer’s disease and Parkinson’s disease. The objective of this review is to highlight the current knowledge about AQPs in the spinal cord and their proposed roles in pathophysiology and pathogenesis related to spinal cord lesions and injury.

AB - Aquaporins (AQPs) are water channel proteins robustly expressed in the central nervous system (CNS). A number of previous studies described the cellular expression sites and investigated their major roles and function in the brain and spinal cord. Among thirteen different mammalian AQPs, AQP1 and AQP4 have been mainly studied in the CNS and evidence has been presented that they play important roles in the pathogenesis of CNS injury, edema and multiple diseases such as multiple sclerosis, neuromyelitis optica spectrum disorders, amyotrophic lateral sclerosis, glioblastoma multiforme, Alzheimer’s disease and Parkinson’s disease. The objective of this review is to highlight the current knowledge about AQPs in the spinal cord and their proposed roles in pathophysiology and pathogenesis related to spinal cord lesions and injury.

KW - Aquaporin

KW - Astrocytes

KW - Central nervous system

KW - Endothelial cells

KW - Neurons

KW - Peripheral nerve

KW - Spinal cord

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Aquaporins in the spinal cord

Abstract

Keywords

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