Abstract
The immediate-type allergic reaction is involved in many allergic diseases such as asthma and allergic rhinitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Artemisia iwayomogi (AIAE) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. AIAE inhibited compound 48/80-induced systemic reactions in mice. AIAE decreased the passive cutaneous anaphylaxis (PCA) reaction activated by antidinitrophenyl (anti-DNP) IgE antibody. AIAE dose-dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. Furthermore, AIAE attenuated the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-α and interleukin-6 secretion in human mast cells. These results provide evidence that AIAE may be beneficial in the treatment of allergic diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 421-430 |
| Number of pages | 10 |
| Journal | Immunopharmacology and Immunotoxicology |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1 Sep 2006 |
Keywords
- Allergic Reaction
- Artemisia iwayomogi
- Interleukin-6
- Mast Cells
- Tumor Necrosis Factor-α
