Artesunate, a potential drug for treatment of Babesia infection

Youn Kyoung Goo; M. Alaa Terkawi; Honglin Jia; G. Oluga Aboge; Hideo Ooka; Bryce Nelson; Suk Kim; Fujiko Sunaga; Kazuhiko Namikawa; Ikuo Igarashi; Yoshifumi Nishikawa; Xuenan Xuan

doi:10.1016/j.parint.2010.06.004

Artesunate, a potential drug for treatment of Babesia infection

Youn Kyoung Goo, M. Alaa Terkawi, Honglin Jia, G. Oluga Aboge, Hideo Ooka, Bryce Nelson, Suk Kim, Fujiko Sunaga, Kazuhiko Namikawa, Ikuo Igarashi, Yoshifumi Nishikawa, Xuenan Xuan

Department of Medicine

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The effects of artesunate, a water-soluble artemisinin derivative, against Babesia species, including Babesia bovis, Babesia gibsoni and Babesia microti were studied. Cultures of B. bovis and B. gibsoni were treated with 0.26, 2.6, 26 and 260μM artesunate, showing inhibition of parasite growth at concentrations equal to and greater than 2.6μM artesunate by days 3 post-treatment for B. gibsoni and B. bovis in a dose-dependent manner. Consistent with in vitro experiments, artesunate was effective in the treatment of mice infected with B. microti at doses equal to and greater than 10. mg/kg of body weight on days 8-10 post-infection. Taken together, these results suggest that artesunate could be a potential drug against Babesia infection.

Original language	English
Pages (from-to)	481-486
Number of pages	6
Journal	Parasitology International
Volume	59
Issue number	3
DOIs	https://doi.org/10.1016/j.parint.2010.06.004
State	Published - Sep 2010

Keywords

Artesunate
Babesia bovis
Babesia gibsoni
Babesia microti

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.parint.2010.06.004

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title = "Artesunate, a potential drug for treatment of Babesia infection",

abstract = "The effects of artesunate, a water-soluble artemisinin derivative, against Babesia species, including Babesia bovis, Babesia gibsoni and Babesia microti were studied. Cultures of B. bovis and B. gibsoni were treated with 0.26, 2.6, 26 and 260μM artesunate, showing inhibition of parasite growth at concentrations equal to and greater than 2.6μM artesunate by days 3 post-treatment for B. gibsoni and B. bovis in a dose-dependent manner. Consistent with in vitro experiments, artesunate was effective in the treatment of mice infected with B. microti at doses equal to and greater than 10. mg/kg of body weight on days 8-10 post-infection. Taken together, these results suggest that artesunate could be a potential drug against Babesia infection.",

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author = "Goo, {Youn Kyoung} and Terkawi, {M. Alaa} and Honglin Jia and Aboge, {G. Oluga} and Hideo Ooka and Bryce Nelson and Suk Kim and Fujiko Sunaga and Kazuhiko Namikawa and Ikuo Igarashi and Yoshifumi Nishikawa and Xuenan Xuan",

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doi = "10.1016/j.parint.2010.06.004",

language = "English",

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AU - Goo, Youn Kyoung

AU - Terkawi, M. Alaa

AU - Jia, Honglin

AU - Aboge, G. Oluga

AU - Ooka, Hideo

AU - Nelson, Bryce

AU - Kim, Suk

AU - Sunaga, Fujiko

AU - Namikawa, Kazuhiko

AU - Igarashi, Ikuo

AU - Nishikawa, Yoshifumi

AU - Xuan, Xuenan

PY - 2010/9

Y1 - 2010/9

N2 - The effects of artesunate, a water-soluble artemisinin derivative, against Babesia species, including Babesia bovis, Babesia gibsoni and Babesia microti were studied. Cultures of B. bovis and B. gibsoni were treated with 0.26, 2.6, 26 and 260μM artesunate, showing inhibition of parasite growth at concentrations equal to and greater than 2.6μM artesunate by days 3 post-treatment for B. gibsoni and B. bovis in a dose-dependent manner. Consistent with in vitro experiments, artesunate was effective in the treatment of mice infected with B. microti at doses equal to and greater than 10. mg/kg of body weight on days 8-10 post-infection. Taken together, these results suggest that artesunate could be a potential drug against Babesia infection.

AB - The effects of artesunate, a water-soluble artemisinin derivative, against Babesia species, including Babesia bovis, Babesia gibsoni and Babesia microti were studied. Cultures of B. bovis and B. gibsoni were treated with 0.26, 2.6, 26 and 260μM artesunate, showing inhibition of parasite growth at concentrations equal to and greater than 2.6μM artesunate by days 3 post-treatment for B. gibsoni and B. bovis in a dose-dependent manner. Consistent with in vitro experiments, artesunate was effective in the treatment of mice infected with B. microti at doses equal to and greater than 10. mg/kg of body weight on days 8-10 post-infection. Taken together, these results suggest that artesunate could be a potential drug against Babesia infection.

KW - Artesunate

KW - Babesia bovis

KW - Babesia gibsoni

KW - Babesia microti

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DO - 10.1016/j.parint.2010.06.004

M3 - Article

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SN - 1383-5769

VL - 59

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EP - 486

JO - Parasitology International

JF - Parasitology International

IS - 3

ER -

Artesunate, a potential drug for treatment of Babesia infection

Abstract

Keywords

UN SDGs

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