Artesunate, a potential drug for treatment of Babesia infection

Youn Kyoung Goo; M. Alaa Terkawi; Honglin Jia; G. Oluga Aboge; Hideo Ooka; Bryce Nelson; Suk Kim; Fujiko Sunaga; Kazuhiko Namikawa; Ikuo Igarashi; Yoshifumi Nishikawa; Xuenan Xuan

doi:10.1016/j.parint.2010.06.004

Artesunate, a potential drug for treatment of Babesia infection

Youn Kyoung Goo
, M. Alaa Terkawi
, Honglin Jia
, G. Oluga Aboge
, Hideo Ooka
, Bryce Nelson
, Suk Kim
, Fujiko Sunaga
, Kazuhiko Namikawa
, Ikuo Igarashi
, Yoshifumi Nishikawa
, Xuenan Xuan

Obihiro University of Agriculture and Veterinary Medicine
Gyeongsang National University
Azabu University

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

The effects of artesunate, a water-soluble artemisinin derivative, against Babesia species, including Babesia bovis, Babesia gibsoni and Babesia microti were studied. Cultures of B. bovis and B. gibsoni were treated with 0.26, 2.6, 26 and 260μM artesunate, showing inhibition of parasite growth at concentrations equal to and greater than 2.6μM artesunate by days 3 post-treatment for B. gibsoni and B. bovis in a dose-dependent manner. Consistent with in vitro experiments, artesunate was effective in the treatment of mice infected with B. microti at doses equal to and greater than 10. mg/kg of body weight on days 8-10 post-infection. Taken together, these results suggest that artesunate could be a potential drug against Babesia infection.

Original language	English
Pages (from-to)	481-486
Number of pages	6
Journal	Parasitology International
Volume	59
Issue number	3
DOIs	https://doi.org/10.1016/j.parint.2010.06.004
State	Published - Sep 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Artesunate
Babesia bovis
Babesia gibsoni
Babesia microti

Access to Document

10.1016/j.parint.2010.06.004

Cite this

@article{b7f72ec760cd45149707eb75a0200c33,

title = "Artesunate, a potential drug for treatment of Babesia infection",

abstract = "The effects of artesunate, a water-soluble artemisinin derivative, against Babesia species, including Babesia bovis, Babesia gibsoni and Babesia microti were studied. Cultures of B. bovis and B. gibsoni were treated with 0.26, 2.6, 26 and 260μM artesunate, showing inhibition of parasite growth at concentrations equal to and greater than 2.6μM artesunate by days 3 post-treatment for B. gibsoni and B. bovis in a dose-dependent manner. Consistent with in vitro experiments, artesunate was effective in the treatment of mice infected with B. microti at doses equal to and greater than 10. mg/kg of body weight on days 8-10 post-infection. Taken together, these results suggest that artesunate could be a potential drug against Babesia infection.",

keywords = "Artesunate, Babesia bovis, Babesia gibsoni, Babesia microti",

author = "Goo, \{Youn Kyoung\} and Terkawi, \{M. Alaa\} and Honglin Jia and Aboge, \{G. Oluga\} and Hideo Ooka and Bryce Nelson and Suk Kim and Fujiko Sunaga and Kazuhiko Namikawa and Ikuo Igarashi and Yoshifumi Nishikawa and Xuenan Xuan",

year = "2010",

month = sep,

doi = "10.1016/j.parint.2010.06.004",

language = "English",

volume = "59",

pages = "481--486",

journal = "Parasitology International",

issn = "1383-5769",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Artesunate, a potential drug for treatment of Babesia infection

AU - Goo, Youn Kyoung

AU - Terkawi, M. Alaa

AU - Jia, Honglin

AU - Aboge, G. Oluga

AU - Ooka, Hideo

AU - Nelson, Bryce

AU - Kim, Suk

AU - Sunaga, Fujiko

AU - Namikawa, Kazuhiko

AU - Igarashi, Ikuo

AU - Nishikawa, Yoshifumi

AU - Xuan, Xuenan

PY - 2010/9

Y1 - 2010/9

N2 - The effects of artesunate, a water-soluble artemisinin derivative, against Babesia species, including Babesia bovis, Babesia gibsoni and Babesia microti were studied. Cultures of B. bovis and B. gibsoni were treated with 0.26, 2.6, 26 and 260μM artesunate, showing inhibition of parasite growth at concentrations equal to and greater than 2.6μM artesunate by days 3 post-treatment for B. gibsoni and B. bovis in a dose-dependent manner. Consistent with in vitro experiments, artesunate was effective in the treatment of mice infected with B. microti at doses equal to and greater than 10. mg/kg of body weight on days 8-10 post-infection. Taken together, these results suggest that artesunate could be a potential drug against Babesia infection.

AB - The effects of artesunate, a water-soluble artemisinin derivative, against Babesia species, including Babesia bovis, Babesia gibsoni and Babesia microti were studied. Cultures of B. bovis and B. gibsoni were treated with 0.26, 2.6, 26 and 260μM artesunate, showing inhibition of parasite growth at concentrations equal to and greater than 2.6μM artesunate by days 3 post-treatment for B. gibsoni and B. bovis in a dose-dependent manner. Consistent with in vitro experiments, artesunate was effective in the treatment of mice infected with B. microti at doses equal to and greater than 10. mg/kg of body weight on days 8-10 post-infection. Taken together, these results suggest that artesunate could be a potential drug against Babesia infection.

KW - Artesunate

KW - Babesia bovis

KW - Babesia gibsoni

KW - Babesia microti

UR - https://www.scopus.com/pages/publications/77955336014

U2 - 10.1016/j.parint.2010.06.004

DO - 10.1016/j.parint.2010.06.004

M3 - Article

C2 - 20541037

AN - SCOPUS:77955336014

SN - 1383-5769

VL - 59

SP - 481

EP - 486

JO - Parasitology International

JF - Parasitology International

IS - 3

ER -

Artesunate, a potential drug for treatment of Babesia infection

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this