TY - JOUR
T1 - Assembly and Biomineralization of Polymorphic Gold–Peptide Superstructures Using Tyrosine-Rich Short Peptides
AU - Kim, Jeong Hwan
AU - Min, Kyoung Ik
N1 - Publisher Copyright:
© 2022 Wiley-VCH GmbH.
PY - 2023/1/20
Y1 - 2023/1/20
N2 - Peptides show tremendous promise in synthesizing metal–peptide superstructures with tailored shapes and functions. However, bottom-up control of the polymorphs of these superstructures using a single short peptide without molecular modification has not been mechanistically clarified. Therefore, an approach to constructing gold–peptide superstructures with unprecedented structural diversity using a tyrosine-rich short peptide is developed, based on the assembling and mineralizing attributes of tyrosine. One-step UV irradiation of peptide/gold-salt systems enables on-site mineralization of gold ions, permitting controlled solvent-dependent fabrication of various superstructures. 0D colloids, 2D sheets, 3D superspheres, and 3D hollow capsules are produced via one-pot reactions in a pH-10 buffer, at the interface of a toluene–water biphasic system, in water, and in toluene-in-water emulsions, respectively, whereas 1D rod/fibril structures are produced using rapidly assembling peptides (A, F, I, L, N, V, Y, and D as X in YY-X-YY) in a two-step process. Several peptide derivatives, which also exhibit assembling and biomineralizing abilities and form various superstructures, validate the functionality of the tyrosine-rich peptide. This study sheds light on the design and development of diverse gold-peptide superstructures for applications including catalysis, sensing, imaging, and photothermal therapy.
AB - Peptides show tremendous promise in synthesizing metal–peptide superstructures with tailored shapes and functions. However, bottom-up control of the polymorphs of these superstructures using a single short peptide without molecular modification has not been mechanistically clarified. Therefore, an approach to constructing gold–peptide superstructures with unprecedented structural diversity using a tyrosine-rich short peptide is developed, based on the assembling and mineralizing attributes of tyrosine. One-step UV irradiation of peptide/gold-salt systems enables on-site mineralization of gold ions, permitting controlled solvent-dependent fabrication of various superstructures. 0D colloids, 2D sheets, 3D superspheres, and 3D hollow capsules are produced via one-pot reactions in a pH-10 buffer, at the interface of a toluene–water biphasic system, in water, and in toluene-in-water emulsions, respectively, whereas 1D rod/fibril structures are produced using rapidly assembling peptides (A, F, I, L, N, V, Y, and D as X in YY-X-YY) in a two-step process. Several peptide derivatives, which also exhibit assembling and biomineralizing abilities and form various superstructures, validate the functionality of the tyrosine-rich peptide. This study sheds light on the design and development of diverse gold-peptide superstructures for applications including catalysis, sensing, imaging, and photothermal therapy.
KW - Au–peptide hybrids
KW - biomineralization
KW - peptide assemblies
KW - superstructures
KW - tyrosine
UR - http://www.scopus.com/inward/record.url?scp=85142214508&partnerID=8YFLogxK
U2 - 10.1002/adfm.202210196
DO - 10.1002/adfm.202210196
M3 - Article
AN - SCOPUS:85142214508
SN - 1616-301X
VL - 33
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 4
M1 - 2210196
ER -