Association between type A blaZ gene polymorphism and cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus

Sun Hee Lee; Wan Beom Park; Shinwon Lee; Sohee Park; Shin Woo Kim; Jong Myung Lee; Hyun Ha Chang; Ki Tae Kwon; Pyoeng Gyun Choe; Nam Joong Kim; Hong Bin Kim; Myoung Don Oh

doi:10.1128/AAC.01517-16

Association between type A blaZ gene polymorphism and cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus

Sun Hee Lee, Wan Beom Park, Shinwon Lee, Sohee Park, Shin Woo Kim, Jong Myung Lee, Hyun Ha Chang, Ki Tae Kwon, Pyoeng Gyun Choe, Nam Joong Kim, Hong Bin Kim, Myoung Don Oh

Department of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Some proportion of type A blaZ gene-positive methicillin-susceptible Staphylococcus aureus strains exhibit the cefazolin inoculum effect (CIE). The type A blaZ gene was divided into two groups by single nucleotide polymorphisms (SNPs) at Ser226Pro and Cys229Tyr. The median cefazolin MICs at a high inoculum concentration were 5.69 μg/ml for the Ser-Cys group and 40.32 μg/ml for the Pro-Tyr group (P = 0.01). The SNPs at codons 226 and 229 in the amino acid sequence encoded by the blaZ gene were closely associated with the CIE.

Original language	English
Pages (from-to)	6928-6932
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	11
DOIs	https://doi.org/10.1128/AAC.01517-16
State	Published - 1 Nov 2016

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Lee, S. H., Park, W. B., Lee, S., Park, S., Kim, S. W., Lee, J. M., Chang, H. H., Kwon, K. T., Choe, P. G., Kim, N. J., Kim, H. B., & Oh, M. D. (2016). Association between type A blaZ gene polymorphism and cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 60(11), 6928-6932. https://doi.org/10.1128/AAC.01517-16

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title = "Association between type A blaZ gene polymorphism and cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus",

abstract = "Some proportion of type A blaZ gene-positive methicillin-susceptible Staphylococcus aureus strains exhibit the cefazolin inoculum effect (CIE). The type A blaZ gene was divided into two groups by single nucleotide polymorphisms (SNPs) at Ser226Pro and Cys229Tyr. The median cefazolin MICs at a high inoculum concentration were 5.69 μg/ml for the Ser-Cys group and 40.32 μg/ml for the Pro-Tyr group (P = 0.01). The SNPs at codons 226 and 229 in the amino acid sequence encoded by the blaZ gene were closely associated with the CIE.",

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AU - Lee, Sun Hee

AU - Park, Wan Beom

AU - Lee, Shinwon

AU - Park, Sohee

AU - Kim, Shin Woo

AU - Lee, Jong Myung

AU - Chang, Hyun Ha

AU - Kwon, Ki Tae

AU - Choe, Pyoeng Gyun

AU - Kim, Nam Joong

AU - Kim, Hong Bin

AU - Oh, Myoung Don

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AB - Some proportion of type A blaZ gene-positive methicillin-susceptible Staphylococcus aureus strains exhibit the cefazolin inoculum effect (CIE). The type A blaZ gene was divided into two groups by single nucleotide polymorphisms (SNPs) at Ser226Pro and Cys229Tyr. The median cefazolin MICs at a high inoculum concentration were 5.69 μg/ml for the Ser-Cys group and 40.32 μg/ml for the Pro-Tyr group (P = 0.01). The SNPs at codons 226 and 229 in the amino acid sequence encoded by the blaZ gene were closely associated with the CIE.

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Association between type A blaZ gene polymorphism and cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus

Abstract

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