TY - JOUR
T1 - Association of 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms with serum alanine aminotransferase activity
AU - Moon, Seong Su
AU - Lee, Young Sil
AU - Kim, Jung Guk
AU - Lee, In Kyu
PY - 2013/3
Y1 - 2013/3
N2 - Aims: 11β-Hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive glucocorticoid to active glucocorticoid, plays a critical role in pathogenesis of non-alcoholic fatty liver disease (NAFLD). Serum alanine aminotransferase (ALT), an indicator of hepatocellular injury, has been suggested as a surrogate marker for NAFLD. To date, no study has specifically examined the relationship between HSD11B1 gene polymorphisms and ALT. Methods: A study was conducted to examine the association of common single nucleotide polymorphisms (SNPs) in HSD11B1 (rs12086634, rs1000283) with serum ALT level in 756 Korean subjects (348 males and 408 females). ALT values were divided into two groups: elevated (>33. U/l in males, >25. U/l in females) and normal. Results: SNPs showed a significant association with elevated ALT. According to results of logistic regression analysis adjusted for confounding variables, the GT. +. GG genotype for rs12086634 and the GA. +. AA genotype for rs1000283 showed significantly higher frequencies of elevated ALT, compared with the TT and GG genotypes, respectively (GT/GG vs. TT; OR 1.685, 95% CI 1.175-2.416, P= 0.005, GA/AA vs. GG; OR 2.057, 95% CI 1.401-3.020, P< 0.001, respectively). Conclusions: HSD11B1 polymorphisms (rs12086634 and rs1000283) are associated with elevated levels of ALT. Findings from this study suggest a possible association between HSD11B1 polymorphisms and hepatocellular injury, such as that seen in patients with NAFLD.
AB - Aims: 11β-Hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive glucocorticoid to active glucocorticoid, plays a critical role in pathogenesis of non-alcoholic fatty liver disease (NAFLD). Serum alanine aminotransferase (ALT), an indicator of hepatocellular injury, has been suggested as a surrogate marker for NAFLD. To date, no study has specifically examined the relationship between HSD11B1 gene polymorphisms and ALT. Methods: A study was conducted to examine the association of common single nucleotide polymorphisms (SNPs) in HSD11B1 (rs12086634, rs1000283) with serum ALT level in 756 Korean subjects (348 males and 408 females). ALT values were divided into two groups: elevated (>33. U/l in males, >25. U/l in females) and normal. Results: SNPs showed a significant association with elevated ALT. According to results of logistic regression analysis adjusted for confounding variables, the GT. +. GG genotype for rs12086634 and the GA. +. AA genotype for rs1000283 showed significantly higher frequencies of elevated ALT, compared with the TT and GG genotypes, respectively (GT/GG vs. TT; OR 1.685, 95% CI 1.175-2.416, P= 0.005, GA/AA vs. GG; OR 2.057, 95% CI 1.401-3.020, P< 0.001, respectively). Conclusions: HSD11B1 polymorphisms (rs12086634 and rs1000283) are associated with elevated levels of ALT. Findings from this study suggest a possible association between HSD11B1 polymorphisms and hepatocellular injury, such as that seen in patients with NAFLD.
KW - 11β-Hydroxysteroid dehydrogenase type 1
KW - Alanine aminotransferase
KW - Metabolic syndrome
KW - Non-alcoholic fatty liver disease
KW - Single nucleotide polymorphism
UR - http://www.scopus.com/inward/record.url?scp=84876163031&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2012.12.020
DO - 10.1016/j.diabres.2012.12.020
M3 - Article
C2 - 23375992
AN - SCOPUS:84876163031
SN - 0168-8227
VL - 99
SP - 343
EP - 350
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 3
ER -