Association of Hepcidin With Anemia Parameters in Incident Dialysis Patients: Differences Between Dialysis Modalities

Jeong Hoon Lim, Yeong Woo Park, Sun Hee Lee, Jun Young Do, Sung Ho Kim, Seungyeup Han, Hee Yeon Jung, Ji Young Choi, Jang Hee Cho, Chan Duck Kim, Sun Hee Park, Yong Lim Kim

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Hepcidin's relationships with other variables are unclear. We evaluated associations of serum hepcidin with clinical parameters in ESRD patients. Ninety-nine incident dialysis patients, including 57 on peritoneal dialysis (PD) and 42 on HD, were prospectively followed for 6 months. Serum hepcidin levels significantly increased during initial 6 months of dialysis. In the multivariate regression model, independent predictors of serum hepcidin levels in ESRD patients before maintenance dialysis were interleukin-6, ferritin, phosphate, iron, and aspartate transaminase. Six months after initiating dialysis, serum hepcidin levels were independently predicted by ferritin, total iron binding capacity (TIBC), and aspartate transaminase in all patients, whereas by ferritin and TIBC in PD patients, and ferritin, TIBC, and 24-h urine volume in HD patients. Serum hepcidin levels are differentially associated with anemia parameters in PD compared with HD patients. Urine volume was an independent predictor of hepcidin levels in early HD patients.

Original languageEnglish
Pages (from-to)4-16
Number of pages13
JournalTherapeutic Apheresis and Dialysis
Volume24
Issue number1
DOIs
StatePublished - 1 Feb 2020

Keywords

  • End-stage renal disease
  • Hemoglobin
  • Hepcidin
  • Iron parameter
  • Urine volume

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