Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in alzheimer's disease

H. Yoon; W. Myung; S. W. Lim; H. S. Kang; S. Kim; H. H. Won; B. J. Carroll; D. K. Kim

doi:10.1055/s-0035-1545300

Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in alzheimer's disease

H. Yoon
, W. Myung
, S. W. Lim
, H. S. Kang
, S. Kim
, H. H. Won
, B. J. Carroll
, D. K. Kim

Department of Psychology

Sungkyunkwan University
Samsung Medical Center, Sungkyunkwan university
Pacific Behavioral Research Foundation

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Introduction: The response to acetylcholinesterase inhibitors (AChEIs) of Alzheimer's disease (AD) patients varies depending on the genetic characteristics of the patient. We have examined the association of response to AChEIs and genetic polymorphisms in AD patients. Methods: 158 patients with AD underwent treatment with AChEIs, and the therapeutic effect was assessed with the Korean version of the Mini Mental State Examination (K-MMSE). The association of 25 SNPs located in 3 genes (CHAT, CHT and ACHE) with changes in the K-MMSE score was analyzed. Results: The response to AChEIs in AD patients was significantly associated with 2 SNPs on the intronic region of CHAT rs2177370 (uncorrected P=0.0025, FDR controlled P=0.026) and rs3793790 (uncorrected P=0.0024, FDR controlled P=0.026). Conclusion: The results of our study confirmed again that genetic polymorphism of CHAT has an influence on drug response in AD.

Original language	English
Pages (from-to)	111-117
Number of pages	7
Journal	Pharmacopsychiatry
Volume	48
Issue number	3
DOIs	https://doi.org/10.1055/s-0035-1545300
State	Published - 1 May 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

acetylcholinesterase inhibitors
Alzheimer's disease
CHAT
drug response

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10.1055/s-0035-1545300

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title = "Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in alzheimer's disease",

abstract = "Introduction: The response to acetylcholinesterase inhibitors (AChEIs) of Alzheimer's disease (AD) patients varies depending on the genetic characteristics of the patient. We have examined the association of response to AChEIs and genetic polymorphisms in AD patients. Methods: 158 patients with AD underwent treatment with AChEIs, and the therapeutic effect was assessed with the Korean version of the Mini Mental State Examination (K-MMSE). The association of 25 SNPs located in 3 genes (CHAT, CHT and ACHE) with changes in the K-MMSE score was analyzed. Results: The response to AChEIs in AD patients was significantly associated with 2 SNPs on the intronic region of CHAT rs2177370 (uncorrected P=0.0025, FDR controlled P=0.026) and rs3793790 (uncorrected P=0.0024, FDR controlled P=0.026). Conclusion: The results of our study confirmed again that genetic polymorphism of CHAT has an influence on drug response in AD.",

keywords = "acetylcholinesterase inhibitors, Alzheimer's disease, CHAT, drug response",

author = "H. Yoon and W. Myung and Lim, \{S. W.\} and Kang, \{H. S.\} and S. Kim and Won, \{H. H.\} and Carroll, \{B. J.\} and Kim, \{D. K.\}",

note = "Publisher Copyright: {\textcopyright} Georg Thieme Verlag KG Stuttgart, New York.",

year = "2015",

month = may,

day = "1",

doi = "10.1055/s-0035-1545300",

language = "English",

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T1 - Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in alzheimer's disease

AU - Yoon, H.

AU - Myung, W.

AU - Lim, S. W.

AU - Kang, H. S.

AU - Kim, S.

AU - Won, H. H.

AU - Carroll, B. J.

AU - Kim, D. K.

N1 - Publisher Copyright: © Georg Thieme Verlag KG Stuttgart, New York.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Introduction: The response to acetylcholinesterase inhibitors (AChEIs) of Alzheimer's disease (AD) patients varies depending on the genetic characteristics of the patient. We have examined the association of response to AChEIs and genetic polymorphisms in AD patients. Methods: 158 patients with AD underwent treatment with AChEIs, and the therapeutic effect was assessed with the Korean version of the Mini Mental State Examination (K-MMSE). The association of 25 SNPs located in 3 genes (CHAT, CHT and ACHE) with changes in the K-MMSE score was analyzed. Results: The response to AChEIs in AD patients was significantly associated with 2 SNPs on the intronic region of CHAT rs2177370 (uncorrected P=0.0025, FDR controlled P=0.026) and rs3793790 (uncorrected P=0.0024, FDR controlled P=0.026). Conclusion: The results of our study confirmed again that genetic polymorphism of CHAT has an influence on drug response in AD.

AB - Introduction: The response to acetylcholinesterase inhibitors (AChEIs) of Alzheimer's disease (AD) patients varies depending on the genetic characteristics of the patient. We have examined the association of response to AChEIs and genetic polymorphisms in AD patients. Methods: 158 patients with AD underwent treatment with AChEIs, and the therapeutic effect was assessed with the Korean version of the Mini Mental State Examination (K-MMSE). The association of 25 SNPs located in 3 genes (CHAT, CHT and ACHE) with changes in the K-MMSE score was analyzed. Results: The response to AChEIs in AD patients was significantly associated with 2 SNPs on the intronic region of CHAT rs2177370 (uncorrected P=0.0025, FDR controlled P=0.026) and rs3793790 (uncorrected P=0.0024, FDR controlled P=0.026). Conclusion: The results of our study confirmed again that genetic polymorphism of CHAT has an influence on drug response in AD.

KW - acetylcholinesterase inhibitors

KW - Alzheimer's disease

KW - CHAT

KW - drug response

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DO - 10.1055/s-0035-1545300

M3 - Article

C2 - 25730470

AN - SCOPUS:84939980952

SN - 0176-3679

VL - 48

SP - 111

EP - 117

JO - Pharmacopsychiatry

JF - Pharmacopsychiatry

IS - 3

ER -

Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in alzheimer's disease

Abstract

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Keywords

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