Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension

Hyun Ae Seo; Su Won Kim; Eon Ju Jeon; Ji Yun Jeong; Seong Su Moon; Won Kee Lee; Jung Guk Kim; In Kyu Lee; Keun Gyu Park

doi:10.1016/j.diabres.2012.04.015

Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension

Hyun Ae Seo, Su Won Kim, Eon Ju Jeon, Ji Yun Jeong, Seong Su Moon, Won Kee Lee, Jung Guk Kim, In Kyu Lee, Keun Gyu Park

Department of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Aims: The aim of this study was to investigate whether the polymorphism of DDAH2 is associated with type 2 diabetes and hypertension in Korean population. Methods: Total 605 subjects were included in this study: 403 patients with type 2 diabetes and 202 non-diabetic control subjects. The SNP rs805304 and rs2272592 in DDAH2 were analyzed. We examined the association of SNP rs805304 and rs2272592 in DDAH2 with type 2 diabetes and hypertension. Results: SNP rs2272592 was significantly associated with type 2 diabetes (P<0.001) while SNP rs805304 was not (P=0.716). We observed that the prevalence of the AG. +. GG genotypes were significantly greater than AA homozygotes in type 2 diabetes (AA vs AG. +. GG; OR 20.74, 95% CI 6.48-66.35, P<0.001). Significance was maintained after adjusting for age, sex, BMI, DBP and BUN (OR 21.03, 95% CI 2.83-151.14, P=0.003). Both SNP rs805304 and rs2272592 in DDAH2 were not significantly associated with hypertension. Conclusions: In the present study, we found that SNP rs2272592 in DDAH2 is associated with type 2 diabetes but SNP rs805304 in DDAH2 is not. DDAH2 SNP rs2272592 AG. +. GG genotypes are associated with genetic susceptibility to type 2 diabetes in Korean population.

Original language	English
Pages (from-to)	125-131
Number of pages	7
Journal	Diabetes Research and Clinical Practice
Volume	98
Issue number	1
DOIs	https://doi.org/10.1016/j.diabres.2012.04.015
State	Published - Oct 2012

Keywords

DDAH2
Hypertension
Polymorphism
Type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2012.04.015

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title = "Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension",

abstract = "Aims: The aim of this study was to investigate whether the polymorphism of DDAH2 is associated with type 2 diabetes and hypertension in Korean population. Methods: Total 605 subjects were included in this study: 403 patients with type 2 diabetes and 202 non-diabetic control subjects. The SNP rs805304 and rs2272592 in DDAH2 were analyzed. We examined the association of SNP rs805304 and rs2272592 in DDAH2 with type 2 diabetes and hypertension. Results: SNP rs2272592 was significantly associated with type 2 diabetes (P<0.001) while SNP rs805304 was not (P=0.716). We observed that the prevalence of the AG. +. GG genotypes were significantly greater than AA homozygotes in type 2 diabetes (AA vs AG. +. GG; OR 20.74, 95% CI 6.48-66.35, P<0.001). Significance was maintained after adjusting for age, sex, BMI, DBP and BUN (OR 21.03, 95% CI 2.83-151.14, P=0.003). Both SNP rs805304 and rs2272592 in DDAH2 were not significantly associated with hypertension. Conclusions: In the present study, we found that SNP rs2272592 in DDAH2 is associated with type 2 diabetes but SNP rs805304 in DDAH2 is not. DDAH2 SNP rs2272592 AG. +. GG genotypes are associated with genetic susceptibility to type 2 diabetes in Korean population.",

keywords = "DDAH2, Hypertension, Polymorphism, Type 2 diabetes",

author = "Seo, {Hyun Ae} and Kim, {Su Won} and Jeon, {Eon Ju} and Jeong, {Ji Yun} and Moon, {Seong Su} and Lee, {Won Kee} and Kim, {Jung Guk} and Lee, {In Kyu} and Park, {Keun Gyu}",

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AU - Seo, Hyun Ae

AU - Kim, Su Won

AU - Jeon, Eon Ju

AU - Jeong, Ji Yun

AU - Moon, Seong Su

AU - Lee, Won Kee

AU - Kim, Jung Guk

AU - Lee, In Kyu

AU - Park, Keun Gyu

PY - 2012/10

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N2 - Aims: The aim of this study was to investigate whether the polymorphism of DDAH2 is associated with type 2 diabetes and hypertension in Korean population. Methods: Total 605 subjects were included in this study: 403 patients with type 2 diabetes and 202 non-diabetic control subjects. The SNP rs805304 and rs2272592 in DDAH2 were analyzed. We examined the association of SNP rs805304 and rs2272592 in DDAH2 with type 2 diabetes and hypertension. Results: SNP rs2272592 was significantly associated with type 2 diabetes (P<0.001) while SNP rs805304 was not (P=0.716). We observed that the prevalence of the AG. +. GG genotypes were significantly greater than AA homozygotes in type 2 diabetes (AA vs AG. +. GG; OR 20.74, 95% CI 6.48-66.35, P<0.001). Significance was maintained after adjusting for age, sex, BMI, DBP and BUN (OR 21.03, 95% CI 2.83-151.14, P=0.003). Both SNP rs805304 and rs2272592 in DDAH2 were not significantly associated with hypertension. Conclusions: In the present study, we found that SNP rs2272592 in DDAH2 is associated with type 2 diabetes but SNP rs805304 in DDAH2 is not. DDAH2 SNP rs2272592 AG. +. GG genotypes are associated with genetic susceptibility to type 2 diabetes in Korean population.

AB - Aims: The aim of this study was to investigate whether the polymorphism of DDAH2 is associated with type 2 diabetes and hypertension in Korean population. Methods: Total 605 subjects were included in this study: 403 patients with type 2 diabetes and 202 non-diabetic control subjects. The SNP rs805304 and rs2272592 in DDAH2 were analyzed. We examined the association of SNP rs805304 and rs2272592 in DDAH2 with type 2 diabetes and hypertension. Results: SNP rs2272592 was significantly associated with type 2 diabetes (P<0.001) while SNP rs805304 was not (P=0.716). We observed that the prevalence of the AG. +. GG genotypes were significantly greater than AA homozygotes in type 2 diabetes (AA vs AG. +. GG; OR 20.74, 95% CI 6.48-66.35, P<0.001). Significance was maintained after adjusting for age, sex, BMI, DBP and BUN (OR 21.03, 95% CI 2.83-151.14, P=0.003). Both SNP rs805304 and rs2272592 in DDAH2 were not significantly associated with hypertension. Conclusions: In the present study, we found that SNP rs2272592 in DDAH2 is associated with type 2 diabetes but SNP rs805304 in DDAH2 is not. DDAH2 SNP rs2272592 AG. +. GG genotypes are associated with genetic susceptibility to type 2 diabetes in Korean population.

KW - DDAH2

KW - Hypertension

KW - Polymorphism

KW - Type 2 diabetes

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Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension

Abstract

Keywords

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