Atherosclerosis

Yuan Yee Lee; Man Hee Rhee

doi:10.1016/B978-0-12-822368-0.00012-8

Atherosclerosis

Yuan Yee Lee, Man Hee Rhee

Department of Veterinary Medicine

Kyungpook National University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Atherosclerosis is a disease that involves a cascade of events. In this chapter, we will run through the cascade of events that contributes to atherosclerosis, how atherosclerosis progresses, and bring up the role of macrophages in atherosclerosis. However, macrophages are not the only player in atherosclerosis. Platelets, monocytes, and macrophages are dependent on each other to facilitate and activate a series of pathways that includes the uptake of lipids by macrophages to form foam cells leading to lipid-rich core formation, plaque rupture, and the activation of platelets leading to a thrombus formation.

Original language	English
Title of host publication	Recent Advancements in Microbial Diversity
Subtitle of host publication	Macrophages and their Role in Inflammation
Publisher	Elsevier
Pages	265-275
Number of pages	11
ISBN (Electronic)	9780128223680
ISBN (Print)	9780128223697
DOIs	https://doi.org/10.1016/B978-0-12-822368-0.00012-8
State	Published - 1 Jan 2022

Keywords

Atherosclerosis
platelet aggregation
thrombosis

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10.1016/B978-0-12-822368-0.00012-8

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AB - Atherosclerosis is a disease that involves a cascade of events. In this chapter, we will run through the cascade of events that contributes to atherosclerosis, how atherosclerosis progresses, and bring up the role of macrophages in atherosclerosis. However, macrophages are not the only player in atherosclerosis. Platelets, monocytes, and macrophages are dependent on each other to facilitate and activate a series of pathways that includes the uptake of lipids by macrophages to form foam cells leading to lipid-rich core formation, plaque rupture, and the activation of platelets leading to a thrombus formation.

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KW - platelet aggregation

KW - thrombosis

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BT - Recent Advancements in Microbial Diversity

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Atherosclerosis

Abstract

Keywords

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