Attenuation of Aβ toxicity by promotion of mitochondrial fusion in neuroblastoma cells by liquiritigenin

Doo Sin Jo; Dong Woon Shin; So Jung Park; Ji Eun Bae; Joon Bum Kim; Na Yeon Park; Jae Sung Kim; Jeong Su Oh; Jung Won Shin; Dong Hyung Cho

doi:10.1007/s12272-016-0780-2

Attenuation of Aβ toxicity by promotion of mitochondrial fusion in neuroblastoma cells by liquiritigenin

Doo Sin Jo, Dong Woon Shin, So Jung Park, Ji Eun Bae, Joon Bum Kim, Na Yeon Park, Jae Sung Kim, Jeong Su Oh, Jung Won Shin, Dong Hyung Cho

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Mitochondrial dynamics control mitochondrial morphology and function, and aberrations in these are associated with various neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. To identify novel regulators of mitochondrial dynamics, we screened a phytochemical library and identified liquiritigenin as a potent inducer of mitochondrial fusion. Treatment with liquiritigenin induced an elongated mitochondrial morphology in SK-N-MC cells. In addition, liquiritigenin rescued mitochondrial fragmentation induced by knockout of mitochondrial fusion mediators such as Mfn1, Mfn2, and Opa1. Furthermore, we found that treatment with liquiritigenin notably inhibited mitochondrial fragmentation and cytotoxicity induced by Aβ in SK-N-MC cells.

Original language	English
Pages (from-to)	1137-1143
Number of pages	7
Journal	Archives of Pharmacal Research
Volume	39
Issue number	8
DOIs	https://doi.org/10.1007/s12272-016-0780-2
State	Published - 1 Aug 2016

Keywords

Amyloid beta
Fusion/fission
Liquiritigenin
Mitochondria dynamics

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title = "Attenuation of Aβ toxicity by promotion of mitochondrial fusion in neuroblastoma cells by liquiritigenin",

abstract = "Mitochondrial dynamics control mitochondrial morphology and function, and aberrations in these are associated with various neurodegenerative diseases including Alzheimer{\textquoteright}s disease and Parkinson{\textquoteright}s disease. To identify novel regulators of mitochondrial dynamics, we screened a phytochemical library and identified liquiritigenin as a potent inducer of mitochondrial fusion. Treatment with liquiritigenin induced an elongated mitochondrial morphology in SK-N-MC cells. In addition, liquiritigenin rescued mitochondrial fragmentation induced by knockout of mitochondrial fusion mediators such as Mfn1, Mfn2, and Opa1. Furthermore, we found that treatment with liquiritigenin notably inhibited mitochondrial fragmentation and cytotoxicity induced by Aβ in SK-N-MC cells.",

keywords = "Amyloid beta, Fusion/fission, Liquiritigenin, Mitochondria dynamics",

author = "Jo, {Doo Sin} and Shin, {Dong Woon} and Park, {So Jung} and Bae, {Ji Eun} and Kim, {Joon Bum} and Park, {Na Yeon} and Kim, {Jae Sung} and Oh, {Jeong Su} and Shin, {Jung Won} and Cho, {Dong Hyung}",

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doi = "10.1007/s12272-016-0780-2",

language = "English",

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T1 - Attenuation of Aβ toxicity by promotion of mitochondrial fusion in neuroblastoma cells by liquiritigenin

AU - Jo, Doo Sin

AU - Shin, Dong Woon

AU - Park, So Jung

AU - Bae, Ji Eun

AU - Kim, Joon Bum

AU - Park, Na Yeon

AU - Kim, Jae Sung

AU - Oh, Jeong Su

AU - Shin, Jung Won

AU - Cho, Dong Hyung

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Mitochondrial dynamics control mitochondrial morphology and function, and aberrations in these are associated with various neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. To identify novel regulators of mitochondrial dynamics, we screened a phytochemical library and identified liquiritigenin as a potent inducer of mitochondrial fusion. Treatment with liquiritigenin induced an elongated mitochondrial morphology in SK-N-MC cells. In addition, liquiritigenin rescued mitochondrial fragmentation induced by knockout of mitochondrial fusion mediators such as Mfn1, Mfn2, and Opa1. Furthermore, we found that treatment with liquiritigenin notably inhibited mitochondrial fragmentation and cytotoxicity induced by Aβ in SK-N-MC cells.

AB - Mitochondrial dynamics control mitochondrial morphology and function, and aberrations in these are associated with various neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. To identify novel regulators of mitochondrial dynamics, we screened a phytochemical library and identified liquiritigenin as a potent inducer of mitochondrial fusion. Treatment with liquiritigenin induced an elongated mitochondrial morphology in SK-N-MC cells. In addition, liquiritigenin rescued mitochondrial fragmentation induced by knockout of mitochondrial fusion mediators such as Mfn1, Mfn2, and Opa1. Furthermore, we found that treatment with liquiritigenin notably inhibited mitochondrial fragmentation and cytotoxicity induced by Aβ in SK-N-MC cells.

KW - Amyloid beta

KW - Fusion/fission

KW - Liquiritigenin

KW - Mitochondria dynamics

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U2 - 10.1007/s12272-016-0780-2

DO - 10.1007/s12272-016-0780-2

M3 - Review article

C2 - 27515055

AN - SCOPUS:84981517806

SN - 0253-6269

VL - 39

SP - 1137

EP - 1143

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 8

ER -

Attenuation of Aβ toxicity by promotion of mitochondrial fusion in neuroblastoma cells by liquiritigenin

Abstract

Keywords

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