Au-Cu2- xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging

Xin Liu; Changho Lee; Wing Cheung Law; Dewei Zhu; Maixian Liu; Mansik Jeon; Jeehyun Kim; Paras N. Prasad; Chulhong Kim; Mark T. Swihart

doi:10.1021/nl402124h

Au-Cu_{2- x}Se heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging

Xin Liu, Changho Lee, Wing Cheung Law, Dewei Zhu, Maixian Liu, Mansik Jeon, Jeehyun Kim, Paras N. Prasad, Chulhong Kim, Mark T. Swihart

School of Electronics Engineering

Research output: Contribution to journal › Article › peer-review

175 Scopus citations

Abstract

We report a new type of heterogeneous nanoparticles (NPs) composed of a heavily doped semiconductor domain (Cu_2-xSe) and a metal domain (Au), which exhibit a broad localized surface plasmon resonance (LSPR) across visible and near-infrared (NIR) wavelengths, arising from interactions between the two nanocrystal domains. We demonstrate both in vivo photoacoustic imaging and in vitro dark field imaging, using the broad LSPR in Cu_2-xSe-Au hybrid NPs to achieve contrast at different wavelengths. The high photoacoustic imaging depth achieved, up to 17 mm, shows that these novel contrast agents could be clinically relevant. More broadly, this work demonstrates a new strategy for tuning LSPR absorbance by engineering the density of free charge carriers in two interacting domains.

Original language	English
Pages (from-to)	4333-4339
Number of pages	7
Journal	Nano Letters
Volume	13
Issue number	9
DOIs	https://doi.org/10.1021/nl402124h
State	Published - 11 Sep 2013

Keywords

contrast agent
heavily doped semiconductor
Localized surface plasmon resonance
metal nanoparticles
photoacoustic imaging

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10.1021/nl402124h

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title = "Au-Cu2- xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging",

abstract = "We report a new type of heterogeneous nanoparticles (NPs) composed of a heavily doped semiconductor domain (Cu2-xSe) and a metal domain (Au), which exhibit a broad localized surface plasmon resonance (LSPR) across visible and near-infrared (NIR) wavelengths, arising from interactions between the two nanocrystal domains. We demonstrate both in vivo photoacoustic imaging and in vitro dark field imaging, using the broad LSPR in Cu2-xSe-Au hybrid NPs to achieve contrast at different wavelengths. The high photoacoustic imaging depth achieved, up to 17 mm, shows that these novel contrast agents could be clinically relevant. More broadly, this work demonstrates a new strategy for tuning LSPR absorbance by engineering the density of free charge carriers in two interacting domains.",

keywords = "contrast agent, heavily doped semiconductor, Localized surface plasmon resonance, metal nanoparticles, photoacoustic imaging",

author = "Xin Liu and Changho Lee and Law, {Wing Cheung} and Dewei Zhu and Maixian Liu and Mansik Jeon and Jeehyun Kim and Prasad, {Paras N.} and Chulhong Kim and Swihart, {Mark T.}",

year = "2013",

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doi = "10.1021/nl402124h",

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journal = "Nano Letters",

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T1 - Au-Cu2- xSe heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging

AU - Liu, Xin

AU - Lee, Changho

AU - Law, Wing Cheung

AU - Zhu, Dewei

AU - Liu, Maixian

AU - Jeon, Mansik

AU - Kim, Jeehyun

AU - Prasad, Paras N.

AU - Kim, Chulhong

AU - Swihart, Mark T.

PY - 2013/9/11

Y1 - 2013/9/11

N2 - We report a new type of heterogeneous nanoparticles (NPs) composed of a heavily doped semiconductor domain (Cu2-xSe) and a metal domain (Au), which exhibit a broad localized surface plasmon resonance (LSPR) across visible and near-infrared (NIR) wavelengths, arising from interactions between the two nanocrystal domains. We demonstrate both in vivo photoacoustic imaging and in vitro dark field imaging, using the broad LSPR in Cu2-xSe-Au hybrid NPs to achieve contrast at different wavelengths. The high photoacoustic imaging depth achieved, up to 17 mm, shows that these novel contrast agents could be clinically relevant. More broadly, this work demonstrates a new strategy for tuning LSPR absorbance by engineering the density of free charge carriers in two interacting domains.

AB - We report a new type of heterogeneous nanoparticles (NPs) composed of a heavily doped semiconductor domain (Cu2-xSe) and a metal domain (Au), which exhibit a broad localized surface plasmon resonance (LSPR) across visible and near-infrared (NIR) wavelengths, arising from interactions between the two nanocrystal domains. We demonstrate both in vivo photoacoustic imaging and in vitro dark field imaging, using the broad LSPR in Cu2-xSe-Au hybrid NPs to achieve contrast at different wavelengths. The high photoacoustic imaging depth achieved, up to 17 mm, shows that these novel contrast agents could be clinically relevant. More broadly, this work demonstrates a new strategy for tuning LSPR absorbance by engineering the density of free charge carriers in two interacting domains.

KW - contrast agent

KW - heavily doped semiconductor

KW - Localized surface plasmon resonance

KW - metal nanoparticles

KW - photoacoustic imaging

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JO - Nano Letters

JF - Nano Letters

IS - 9

ER -

Au-Cu_{2- x}Se heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging

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Keywords

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