Autophagy induced by resveratrol suppresses α-MSH-induced melanogenesis

Eun Sung Kim, Huikyoung Chang, Hyunjung Choi, Ji Hyun Shin, So Jung Park, Yoon Kyung Jo, Eun Sun Choi, Seok Yun Baek, Byung Gyu Kim, Jong Wook Chang, Jin Cheon Kim, Dong Hyung Cho

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Autophagy degrades cellular components and organelles through a cooperative process involving autophagosomes and lysosomes. Although autophagy is known to mainly regulate the turnover of cellular components, the role of autophagy in melanogenesis has not been well addressed. Here, we show that inhibition of autophagy suppresses the antimelanogenesis activity of resveratrol (RSV), a well-known antimelanogenic agent. RSV strongly increased autophagy in melanocytes. However, the depletion of ATG5 significantly suppressed RSV-mediated antimelanogenesis as well as RSV-induced autophagy in melanocytes. Moreover, suppression of ATG5 retrieved the RSV-mediated downregulation of tyrosinase and TRP1 in α-MSH-treated cells. Most importantly, electron microscopy analysis revealed that autophagosomes engulfed melanin or melanosomes after combined treatment of α-MSH and RSV. Taken together, these results suggest that RSV-mediated autophagy regulates melanogenesis.

Original languageEnglish
Pages (from-to)204-206
Number of pages3
JournalExperimental Dermatology
Volume23
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • Autophagy
  • Melanocytes
  • Melanogenesis
  • Resveratrol

Fingerprint

Dive into the research topics of 'Autophagy induced by resveratrol suppresses α-MSH-induced melanogenesis'. Together they form a unique fingerprint.

Cite this