Bacterial Profiles of Brain in Downer Cattle with Unknown Etiology

Yeong Jun Park, Gi Ung Kang, Minsoo Jeong, Vineet Singh, Jongho Kim, Kyunghyun Lee, Eun Jin Choi, Heui Jin Kim, Seungjun Lee, Sook Young Lee, Jae Ku Oem, Jae Ho Shin

Research output: Contribution to journalArticlepeer-review

Abstract

Downer cow can be caused by muscular paralysis, neurological damage, metabolic disorder, and/or the complication of microbial infection. However, downer cow with unknown etiology is issued because of the non-detection of its bacterial etiological agent. In this study, differences in the bacterial community in brain tissues between downer cattle with unknown etiology and healthy slaughtered cattle are investigated. Bacterial diversity and representative genera between downer and normal cattle were significantly different (p < 0.05). There are significant differences in representative genera of downer and normal cattle, especially the significance, fold change, and area under the receiver operating characteristic curve score (p < 0.05). Furthermore, the prediction of functional genes in brain microbiota between the downer and normal cattle revealed differences in the cluster of orthologous gene categories, such as lipid transport and metabolism, secondary metabolite biosynthesis, and signal transduction (p < 0.05). This study revealed a significant difference in microbiota between the downer and normal cattle. Thus, we demonstrate that representative genera from downer cattle through 16S rRNA gene amplicon sequencing and microbiota analysis have the potential as candidates for bacterial etiological agents for downer cow.

Original languageEnglish
Article number98
JournalMicroorganisms
Volume11
Issue number1
DOIs
StatePublished - Jan 2023

Keywords

  • brain microbiota
  • downer cow
  • next-generation sequencing
  • unknown etiology

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