BFGF enhances the IGFs-mediated pluripotent and differentiation potentials in multipotent stem cells

Sang Bum Park, Kyung Rok Yu, Ji Won Jung, Sae Rom Lee, Kyoung Hwan Roh, Min Soo Seo, Jeong Ran Park, Soo Kyung Kang, Yong Soon Lee, Kyung Sun Kang

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

It has widely been reported that basic fibroblast growth factor (bFGF) promotes proliferation of human stem cells and contributes to the maintenance of their self-renewal capability through repeated replications. In contrast to embryonic stem cells (ESCs), the effects of growth factors on adult stem cells are poorly understood.In human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs), bFGF is associated with an increased number of proliferating cells. Furthermore, expression levels of ESC markers were increased after treatment with bFGF. bFGF also increased the expression of FGFR, which in turn increased expression of insulin-like growth factor (IGFs). Since IGFs exert autocrine and paracrine effects on stem cells, bFGF-mediated release of IGFs from hUCB-MSCs might enhance FGFR1 and IGF1R expression in neighboring cells. These receptors could subsequently regulate the effects of bFGF and IGFs in adult stem cells.These results suggest that positive feedback regulation of bFGF and IGFs leads to proliferation of hUCB-MSCs.

Original languageEnglish
Pages (from-to)425-437
Number of pages13
JournalGrowth Factors
Volume27
Issue number6
DOIs
StatePublished - Dec 2009

Keywords

  • BFGF
  • FGFR1
  • IGF
  • IGF1R
  • Multipotent stem cells
  • Umbilical cord blood

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