Bilateral enhancement of excitation via up-regulation of vesicular glutamate transporter subtype 1, not subtype 2, immunoreactivity in the unilateral hypoxic epilepsy model

Duk Soo Kim, Sung Eun Kwak, Ji Eun Kim, Ho Won Moo, Hui Chul Choi, Hong Ki Song, Oh Shin Kwon, Yeong In Kim, Soo Young Choi, Tae Cheon Kang

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

In the present study, the change of vesicular glutamate transporter (VGLUT) immunoreactivity on long-term impaired excitability in the hippocampus after recovery from unilateral hypoxic-ischemic insult was investigated in order to extend our understanding of the mechanism of epileptogenesis using unilateral hypoxic epilepsy models. Both the lesioned (submitted to ischemia) and the unlesioned hippocampi exhibited the frequent occurrence of interictal spikes and occasionally the sustained ictal discharges. However, paired-pulse inhibition was significantly reduced in the unlesioned dentate gyrus, not in the lesioned dentate gyrus. VGLUT1 immunoreactivity was significantly elevated in both hippocampi following hypoxic ischemia, although VGLUT2 immunodensity was unaltered. These findings suggest that the enhancement of VGLUT1 immunoreactivity in both hippocampi after unilateral hypoxic ischemia may contribute to the hyperexcitability, which may play an important role in the epileptogenesis (presumably accompanied by altered inhibitory transmission) after neurodegeneration.

Original languageEnglish
Pages (from-to)122-130
Number of pages9
JournalBrain Research
Volume1055
Issue number1-2
DOIs
StatePublished - 7 Sep 2005

Keywords

  • Diaschisis
  • Epilepsy
  • Hippocampus
  • Paired pulse response
  • Vesicular glutamate transporter

Fingerprint

Dive into the research topics of 'Bilateral enhancement of excitation via up-regulation of vesicular glutamate transporter subtype 1, not subtype 2, immunoreactivity in the unilateral hypoxic epilepsy model'. Together they form a unique fingerprint.

Cite this