Bio-nanohybrids based on layered double hydroxide

Jin Ho Choy, Man Park, Jae Min Oh

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Layered double hydroxides (LDHs) with high anion exchange capacity have attracted particular attention in the fields of bio-hybrid nanomaterials due to their unique properties such as excellent biocompatibility, high affinity to carbonate anion, pH-dependent stability and high availability. To date, a variety of negatively charged biomolecules have been hybridized with LDHs to evolve into bio-LDH nanohybrids, including vitamins, drugs and DNA strands as well as simple organic acids. Bio-LDH nanohybrids can be readily prepared in a mild condition by coprecipitation, anion exchange or reconstruction. Their applications can be found in a wide range from the controlled release and delivery systems to biosensors and genetic molecular code system. In this review, special emphasis has been placed on DNA-LDH nanohybrids because DNA molecules are of great importance in many sciences and industrial fields. Their synthesis methods, characteristics and application potentials are reviewed briefly.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalCurrent Nanoscience
Volume2
Issue number3
DOIs
StatePublished - Aug 2006

Keywords

  • Bio-nanohybrids
  • Cellular uptake
  • DNA-LDH nanohybrid
  • Gene delivery
  • Genetic code system

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