Bioactive 3,4-seco-triterpenoids from the fruits of Acanthopanax sessiliflorus

Dae Young Lee; Kyeong Hwa Seo; Dong Sung Lee; Youn Chul Kim; In Sik Chung; Gye Won Kim; Dae Sung Cheoi; Nam In Baek

doi:10.1021/np3002173

Bioactive 3,4-seco-triterpenoids from the fruits of Acanthopanax sessiliflorus

Dae Young Lee
, Kyeong Hwa Seo
, Dong Sung Lee
, Youn Chul Kim
, In Sik Chung
, Gye Won Kim
, Dae Sung Cheoi
, Nam In Baek

School of Life Science and Biotechnology

Kyung Hee University
Wonkwang University
Hankyong National University
Jeongseon Agricultural Extension Center

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Eight new 3,4-seco-lupane triterpenes and glycosides, acanthosessiligenins I and II (1, 3) and acanthosessiliosides A-F (2, 4-8), as well as six known 3,4-seco-lupane triterpenes (9-14) were isolated from an ethanolic extract of Acanthopanax sessilif lorus fruits. The chemical structures of 1-8 were determined by spectroscopic data interpretation. All isolated compounds were tested for their cytotoxicity against six human cancer cell lines and their ability to inhibit LPSinduced nitric oxide production in RAW 264.7 macrophages.

Original language	English
Pages (from-to)	1138-1144
Number of pages	7
Journal	Journal of Natural Products
Volume	75
Issue number	6
DOIs	https://doi.org/10.1021/np3002173
State	Published - 22 Jun 2012

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10.1021/np3002173

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title = "Bioactive 3,4-seco-triterpenoids from the fruits of Acanthopanax sessiliflorus",

abstract = "Eight new 3,4-seco-lupane triterpenes and glycosides, acanthosessiligenins I and II (1, 3) and acanthosessiliosides A-F (2, 4-8), as well as six known 3,4-seco-lupane triterpenes (9-14) were isolated from an ethanolic extract of Acanthopanax sessilif lorus fruits. The chemical structures of 1-8 were determined by spectroscopic data interpretation. All isolated compounds were tested for their cytotoxicity against six human cancer cell lines and their ability to inhibit LPSinduced nitric oxide production in RAW 264.7 macrophages.",

author = "Lee, \{Dae Young\} and Seo, \{Kyeong Hwa\} and Lee, \{Dong Sung\} and Kim, \{Youn Chul\} and Chung, \{In Sik\} and Kim, \{Gye Won\} and Cheoi, \{Dae Sung\} and Baek, \{Nam In\}",

year = "2012",

month = jun,

day = "22",

doi = "10.1021/np3002173",

language = "English",

volume = "75",

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T1 - Bioactive 3,4-seco-triterpenoids from the fruits of Acanthopanax sessiliflorus

AU - Lee, Dae Young

AU - Seo, Kyeong Hwa

AU - Lee, Dong Sung

AU - Kim, Youn Chul

AU - Chung, In Sik

AU - Kim, Gye Won

AU - Cheoi, Dae Sung

AU - Baek, Nam In

PY - 2012/6/22

Y1 - 2012/6/22

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AB - Eight new 3,4-seco-lupane triterpenes and glycosides, acanthosessiligenins I and II (1, 3) and acanthosessiliosides A-F (2, 4-8), as well as six known 3,4-seco-lupane triterpenes (9-14) were isolated from an ethanolic extract of Acanthopanax sessilif lorus fruits. The chemical structures of 1-8 were determined by spectroscopic data interpretation. All isolated compounds were tested for their cytotoxicity against six human cancer cell lines and their ability to inhibit LPSinduced nitric oxide production in RAW 264.7 macrophages.

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DO - 10.1021/np3002173

M3 - Article

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AN - SCOPUS:84866452298

SN - 0163-3864

VL - 75

SP - 1138

EP - 1144

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 6

ER -

Bioactive 3,4-seco-triterpenoids from the fruits of Acanthopanax sessiliflorus

Abstract

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