Biocompatibility of phema and P(Hema-Co-Sma) hydrogels

Bo Hyung Park; Young A. Han; Jin Hyun Choi; Jeong Ok Lim

doi:10.4028/0-87849-958-x.51

Biocompatibility of phema and P(Hema-Co-Sma) hydrogels

Bo Hyung Park, Young A. Han, Jin Hyun Choi, Jeong Ok Lim

Department of Biofibers and Biomaterials Science

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

To replace a poly(2-hydroxyethyl methacrylate) (PHEMA) sponge, which has limited applications as an implant material, PHEMA and poly(2-hydroxyethyl methacrylate-co-sodium methacrylate) (P(HEMA-co-SMA)) hydrogels with enhanced biocompatibility were prepared based on the copolymerization of 2-hydroxyethyl methacrylate (HEMA) and sodium methacrylate (SMA) at a high monomer concentration. When the cytotoxicity, cell adhesion, and in vivo tissue reaction of the resulting hydrogels were investigated, the results suggest that hydrogels prepared by the copolymerization of HEMA and SMA at a high monomer concentration have great potential as implant materials with an excellent biocompatibility.

Original language	English
Pages (from-to)	51-55
Number of pages	5
Journal	Key Engineering Materials
Volume	277-279
Issue number	I
DOIs	https://doi.org/10.4028/0-87849-958-x.51
State	Published - 2005

Keywords

Biocompatibility
Biomaterials
Cell adhesion
Cytotoxicity
Implantation
in vivo tissue reaction
Mechanically strong hydrogel
P(HEMA-co-SMA)
PHEMA

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title = "Biocompatibility of phema and P(Hema-Co-Sma) hydrogels",

abstract = "To replace a poly(2-hydroxyethyl methacrylate) (PHEMA) sponge, which has limited applications as an implant material, PHEMA and poly(2-hydroxyethyl methacrylate-co-sodium methacrylate) (P(HEMA-co-SMA)) hydrogels with enhanced biocompatibility were prepared based on the copolymerization of 2-hydroxyethyl methacrylate (HEMA) and sodium methacrylate (SMA) at a high monomer concentration. When the cytotoxicity, cell adhesion, and in vivo tissue reaction of the resulting hydrogels were investigated, the results suggest that hydrogels prepared by the copolymerization of HEMA and SMA at a high monomer concentration have great potential as implant materials with an excellent biocompatibility.",

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T1 - Biocompatibility of phema and P(Hema-Co-Sma) hydrogels

AU - Park, Bo Hyung

AU - Han, Young A.

AU - Choi, Jin Hyun

AU - Lim, Jeong Ok

PY - 2005

Y1 - 2005

N2 - To replace a poly(2-hydroxyethyl methacrylate) (PHEMA) sponge, which has limited applications as an implant material, PHEMA and poly(2-hydroxyethyl methacrylate-co-sodium methacrylate) (P(HEMA-co-SMA)) hydrogels with enhanced biocompatibility were prepared based on the copolymerization of 2-hydroxyethyl methacrylate (HEMA) and sodium methacrylate (SMA) at a high monomer concentration. When the cytotoxicity, cell adhesion, and in vivo tissue reaction of the resulting hydrogels were investigated, the results suggest that hydrogels prepared by the copolymerization of HEMA and SMA at a high monomer concentration have great potential as implant materials with an excellent biocompatibility.

AB - To replace a poly(2-hydroxyethyl methacrylate) (PHEMA) sponge, which has limited applications as an implant material, PHEMA and poly(2-hydroxyethyl methacrylate-co-sodium methacrylate) (P(HEMA-co-SMA)) hydrogels with enhanced biocompatibility were prepared based on the copolymerization of 2-hydroxyethyl methacrylate (HEMA) and sodium methacrylate (SMA) at a high monomer concentration. When the cytotoxicity, cell adhesion, and in vivo tissue reaction of the resulting hydrogels were investigated, the results suggest that hydrogels prepared by the copolymerization of HEMA and SMA at a high monomer concentration have great potential as implant materials with an excellent biocompatibility.

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KW - Biomaterials

KW - Cell adhesion

KW - Cytotoxicity

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KW - in vivo tissue reaction

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Biocompatibility of phema and P(Hema-Co-Sma) hydrogels

Abstract

Keywords

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