Bioimpedance-Guided Fluid Removal in Continuous KRT: The VENUS Randomized Clinical Trial

Jung Nam An, Hyung Jung Oh, Sohee Oh, Harin Rhee, Eun Young Seong, Seon Ha Baek, Shin Young Ahn, Jang Hee Cho, Jung Pyo Lee, Dong Ki Kim, Dong Ryeol Ryu, Soyeon Ahn, Sejoong Kim

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Abstract

Key PointsThis study, the sole randomized trial of its kind, proposes guidelines for fluid balance management in continuous KRT (CKRT) patients using bioimpedance.Despite this, bioimpedance analysis-guided volume management did not influence the proportion of patients achieving estimated euvolemia at 7 days into CKRT.Further investigation is needed to assess whether bioimpedance analysis guidance can facilitate rapid fluid removal in the early phase of CKRT for patients with AKI.BackgroundUltrafiltration with continuous KRT (CKRT) can be used to manage fluid balance in critically ill patients with AKI. We aimed to assess whether bioimpedance analysis (BIA)-guided volume management was more efficacious than conventional management for achieving estimated euvolemia (e-euvolemia) in CKRT-Treated patients.MethodsIn a multicenter randomized controlled trial from July 2017 to July 2020, the patients with AKI requiring CKRT were eligible if the weight at the start of CKRT had increased by ≥5% compared with the weight at the time of admission or total body water (TBW)/height (H)2≥13 L/m2. We randomly assigned 208 patients to the control (conventional fluid management; n=103) and intervention groups (BIA-guided fluid management; n=105). The primary outcome was the proportion of attaining e-euvolemia 7 days postrandomization. E-euvolemia was defined as the difference between TBW/H2D7and D0was <-2.1 L/m2, or when TBW/H2measured on D7was <13 L/m2. The 28-, 60-, and 90-day mortality rate were secondary outcomes.ResultsThe primary outcome occurred in 34 patients in the intervention group and 27 in the control group (47% versus 41%; P = 0.50). The mean value of TBW/H2measured on D7was the same at 13.9 L/m2in both groups. The differences between TBW/H2D7and D0were-1.13 L/m2in the intervention group and-1.08 L/m2in the control group (P = 0.84). Patients in the intervention group had a significantly higher proportion of reaching e-euvolemia on D1than those in the control group (13% versus 4%, P = 0.02). Adverse events did not differ significantly between the groups.ConclusionsBIA-guided volume management did not affect the proportion of reaching the e-euvolemia at 7 days of the start of CKRT.Clinical Trial registry name and registration number:ClinicalTrials.gov, ID: NCT03330626 (Registered on November 6, 2017; seven study participants were retrospectively registered; nonetheless, Institutional Review Board approval of each institution was completed before study participant registration).

Original languageEnglish
Pages (from-to)1527-1536
Number of pages10
JournalClinical Journal of the American Society of Nephrology
Volume19
Issue number12
DOIs
StatePublished - 1 Dec 2024

Keywords

  • AKI

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