Biological and pharmacological effects of pinusolide, a novel platelet activating factor antagonist

H. O. Yang, Y. H. Kang, D. Y. Suh, Y. C. Kim, B. H. Han

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Pinusolide, a potent platelet activating factor (PAF) receptor binding antagonist, inhibited PAF-induced aggregation of rabbit platelets with an IC50 value of 5 μM, whereas no inhibitory effects on the aggregation induced by ADP, thrombin, and collagen were observed. Pinusolide protected the mice from PAF-induced lethality with ED50 values of 1.1 mg/kg, i.v. and 69 mg/kg, p.o. Topically given pinusolide at 2 mg/ear effectively inhibited croton oil induced mouse ear edema. All the pinusolide treated ears recovered to normal healthy appearance in a sharp contrast to totally necrotized untreated ears. These results indicated that pinusolide is a potent and specific PAF antagonist in all experimental models as shown in vitro, in vivo, and in animal tests.

Original languageEnglish
Pages (from-to)519-522
Number of pages4
JournalPlanta Medica
Volume61
Issue number6
DOIs
StatePublished - 1995

Keywords

  • Biota orientalis
  • croton oil
  • cupressaceae
  • PAF-induced lethality
  • pinusolide
  • platelet activating factor (PAF) antagonist
  • topical anti-inflammatory activity

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