Abstract
Pinusolide, a potent platelet activating factor (PAF) receptor binding antagonist, inhibited PAF-induced aggregation of rabbit platelets with an IC50 value of 5 μM, whereas no inhibitory effects on the aggregation induced by ADP, thrombin, and collagen were observed. Pinusolide protected the mice from PAF-induced lethality with ED50 values of 1.1 mg/kg, i.v. and 69 mg/kg, p.o. Topically given pinusolide at 2 mg/ear effectively inhibited croton oil induced mouse ear edema. All the pinusolide treated ears recovered to normal healthy appearance in a sharp contrast to totally necrotized untreated ears. These results indicated that pinusolide is a potent and specific PAF antagonist in all experimental models as shown in vitro, in vivo, and in animal tests.
Original language | English |
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Pages (from-to) | 519-522 |
Number of pages | 4 |
Journal | Planta Medica |
Volume | 61 |
Issue number | 6 |
DOIs | |
State | Published - 1995 |
Keywords
- Biota orientalis
- croton oil
- cupressaceae
- PAF-induced lethality
- pinusolide
- platelet activating factor (PAF) antagonist
- topical anti-inflammatory activity