Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites

Joseph W. Song; Hanjun Ryu; Wubin Bai; Zhaoqian Xie; Abraham Vázquez-Guardado; Khizar Nandoliya; Raudel Avila; Geumbee Lee; Zhen Song; Jihye Kim; Min Kyu Lee; Yugang Liu; Mirae Kim; Huifeng Wang; Yixin Wu; Hong Joon Yoon; Sung Soo Kwak; Jaeho Shin; Kyeongha Kwon; Wei Lu; Xuexian Chen; Yonggang Huang; Guillermo A. Ameer; John A. Rogers

doi:10.1126/sciadv.ade4687

Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites

Joseph W. Song, Hanjun Ryu, Wubin Bai, Zhaoqian Xie, Abraham Vázquez-Guardado, Khizar Nandoliya, Raudel Avila, Geumbee Lee, Zhen Song, Jihye Kim, Min Kyu Lee, Yugang Liu, Mirae Kim, Huifeng Wang, Yixin Wu, Hong Joon Yoon, Sung Soo Kwak, Jaeho Shin, Kyeongha Kwon, Wei LuXuexian Chen, Yonggang Huang, Guillermo A. Ameer, John A. Rogers

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.

Original language	English
Article number	eade4687
Journal	Science advances
Volume	9
Issue number	8
DOIs	https://doi.org/10.1126/sciadv.ade4687
State	Published - Feb 2023

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10.1126/sciadv.ade4687

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Song, J. W., Ryu, H., Bai, W., Xie, Z., Vázquez-Guardado, A., Nandoliya, K., Avila, R., Lee, G., Song, Z., Kim, J., Lee, M. K., Liu, Y., Kim, M., Wang, H., Wu, Y., Yoon, H. J., Kwak, S. S., Shin, J., Kwon, K., ... Rogers, J. A. (2023). Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites. Science advances, 9(8), Article eade4687. https://doi.org/10.1126/sciadv.ade4687

@article{da11907fda184e42860aa2aa336dd826,

title = "Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites",

abstract = "Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.",

author = "Song, {Joseph W.} and Hanjun Ryu and Wubin Bai and Zhaoqian Xie and Abraham V{\'a}zquez-Guardado and Khizar Nandoliya and Raudel Avila and Geumbee Lee and Zhen Song and Jihye Kim and Lee, {Min Kyu} and Yugang Liu and Mirae Kim and Huifeng Wang and Yixin Wu and Yoon, {Hong Joon} and Kwak, {Sung Soo} and Jaeho Shin and Kyeongha Kwon and Wei Lu and Xuexian Chen and Yonggang Huang and Ameer, {Guillermo A.} and Rogers, {John A.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science.",

year = "2023",

month = feb,

doi = "10.1126/sciadv.ade4687",

language = "English",

volume = "9",

journal = "Science advances",

issn = "2375-2548",

publisher = "American Association for the Advancement of Science",

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Song, JW, Ryu, H, Bai, W, Xie, Z, Vázquez-Guardado, A, Nandoliya, K, Avila, R, Lee, G, Song, Z, Kim, J, Lee, MK, Liu, Y, Kim, M, Wang, H, Wu, Y, Yoon, HJ, Kwak, SS, Shin, J, Kwon, K, Lu, W, Chen, X, Huang, Y, Ameer, GA & Rogers, JA 2023, 'Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites', Science advances, vol. 9, no. 8, eade4687. https://doi.org/10.1126/sciadv.ade4687

TY - JOUR

T1 - Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites

AU - Song, Joseph W.

AU - Ryu, Hanjun

AU - Bai, Wubin

AU - Xie, Zhaoqian

AU - Vázquez-Guardado, Abraham

AU - Nandoliya, Khizar

AU - Avila, Raudel

AU - Lee, Geumbee

AU - Song, Zhen

AU - Kim, Jihye

AU - Lee, Min Kyu

AU - Liu, Yugang

AU - Kim, Mirae

AU - Wang, Huifeng

AU - Wu, Yixin

AU - Yoon, Hong Joon

AU - Kwak, Sung Soo

AU - Shin, Jaeho

AU - Kwon, Kyeongha

AU - Lu, Wei

AU - Chen, Xuexian

AU - Huang, Yonggang

AU - Ameer, Guillermo A.

AU - Rogers, John A.

PY - 2023/2

Y1 - 2023/2

N2 - Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.

AB - Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.

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U2 - 10.1126/sciadv.ade4687

DO - 10.1126/sciadv.ade4687

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AN - SCOPUS:85148551109

SN - 2375-2548

VL - 9

JO - Science advances

JF - Science advances

IS - 8

M1 - eade4687

ER -

Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites

Abstract

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