TY - JOUR
T1 - Biotechnological valorization of levulinic acid as a non-sugar feedstock
T2 - New paradigm in biorefineries
AU - Kim, Dong Hyun
AU - Cha, Jaehyun
AU - Woo Park, Gwon
AU - Soo Kang, Im
AU - Lee, Eunjin
AU - Hoon Jung, Young
AU - Min, Kyoungseon
N1 - Publisher Copyright:
© 2024
PY - 2024/9
Y1 - 2024/9
N2 - Due to the severe climate crisis, biorefineries have been highlighted as replacements for fossil fuel-derived refineries. In traditional sugar-based biorefineries, levulinic acid (LA) is a byproduct. Nonetheless, in 2002, the US Department of Energy noted that LA is a significant building block obtained from biomass, and the biorefinery paradigm has shifted from being sugar-based to non-sugar-based. Accordingly, LA is of interest in this review since it can be converted into useful precursors and ultimately can broaden the product spectrum toward more valuable products (e.g., fuels, plastics, and pharmaceuticals), thereby enabling the construction of economically viable biorefineries. This study comprehensively reviews LA production techniques utilizing various bioresources. Recent progress in enzymatic and microbial routes for LA valorization and the LA-derived product spectrum and its versatility are discussed. Finally, challenges and future outlooks for LA-based non-sugar biorefineries are suggested.
AB - Due to the severe climate crisis, biorefineries have been highlighted as replacements for fossil fuel-derived refineries. In traditional sugar-based biorefineries, levulinic acid (LA) is a byproduct. Nonetheless, in 2002, the US Department of Energy noted that LA is a significant building block obtained from biomass, and the biorefinery paradigm has shifted from being sugar-based to non-sugar-based. Accordingly, LA is of interest in this review since it can be converted into useful precursors and ultimately can broaden the product spectrum toward more valuable products (e.g., fuels, plastics, and pharmaceuticals), thereby enabling the construction of economically viable biorefineries. This study comprehensively reviews LA production techniques utilizing various bioresources. Recent progress in enzymatic and microbial routes for LA valorization and the LA-derived product spectrum and its versatility are discussed. Finally, challenges and future outlooks for LA-based non-sugar biorefineries are suggested.
KW - Enzymatic routes for valorizing LA
KW - Levulinic acid (LA)
KW - Metabolic pathways for utilizing LA
KW - Various bioresources for producing LA
UR - http://www.scopus.com/inward/record.url?scp=85200027718&partnerID=8YFLogxK
U2 - 10.1016/j.biortech.2024.131178
DO - 10.1016/j.biortech.2024.131178
M3 - Review article
C2 - 39084536
AN - SCOPUS:85200027718
SN - 0960-8524
VL - 408
JO - Bioresource Technology
JF - Bioresource Technology
M1 - 131178
ER -