Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging

Mohammad Yaseen Ahmad; Shuwen Liu; Tirusew Tegafaw; Abdullah Khamis Ali Al Saidi; Dejun Zhao; Ying Liu; Sangyeol Lee; Seungho Kim; So Hyeon Yang; Dong Wook Hwang; Ahrum Baek; Jae Chang Jung; Sung Wook Nam; Kwon Seok Chae; Yongmin Chang; Gang Ho Lee

doi:10.1002/ejic.202300430

Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging

Mohammad Yaseen Ahmad, Shuwen Liu, Tirusew Tegafaw, Abdullah Khamis Ali Al Saidi, Dejun Zhao, Ying Liu, Sangyeol Lee, Seungho Kim, So Hyeon Yang, Dong Wook Hwang, Ahrum Baek, Jae Chang Jung, Sung Wook Nam, Kwon Seok Chae, Yongmin Chang, Gang Ho Lee

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

Abstract

Herein, biotin (Bio)-conjugated poly(acrylic acid) (PAA)-grafted ultrasmall gadolinium oxide nanoparticles (Bio-PAA-Gd₂O₃ NPs) were synthesized for enhanced tumor imaging using Bio as a tumor-targeting ligand. The average particle diameter of Gd₂O₃ NPs was 2.1 nm. The Bio-PAA-Gd₂O₃ NPs exhibited excellent colloidal stability (i. e., no precipitation) and a high longitudinal water proton spin relaxivity (r₁) of 23.8 s⁻¹ mM⁻¹ (r₂/r₁=1.6 and r₂=transverse water proton spin relaxivity), which was ∼6 times higher than those of commercial Gd-chelated magnetic resonance imaging (MRI) contrast agents. Cytotoxicity tests using two cell lines showed that the Bio-PAA-Gd₂O₃ NPs were almost non-toxic up to the measured concentration of 500 μM Gd. The enhanced tumor imaging of the Bio-PAA-Gd₂O₃ NPs was demonstrated through their higher positive contrasts and longer contrast retention at the tumor after intravenous injection in T₁ MR images, compared with those of the control PAA-Gd₂O₃ NPs.

Original language	English
Article number	e202300430
Journal	European Journal of Inorganic Chemistry
Volume	26
Issue number	27
DOIs	https://doi.org/10.1002/ejic.202300430
State	Published - 25 Sep 2023

Keywords

biotin
magnetic resonance imaging
nanoparticles
tumor models
tumor targeting

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10.1002/ejic.202300430

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Ahmad, M. Y., Liu, S., Tegafaw, T., Al Saidi, A. K. A., Zhao, D., Liu, Y., Lee, S., Kim, S., Yang, S. H., Hwang, D. W., Baek, A., Jung, J. C., Nam, S. W., Chae, K. S., Chang, Y., & Lee, G. H. (2023). Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging. European Journal of Inorganic Chemistry, 26(27), Article e202300430. https://doi.org/10.1002/ejic.202300430

@article{f71e580477be480781b56998ac885986,

title = "Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging",

abstract = "Herein, biotin (Bio)-conjugated poly(acrylic acid) (PAA)-grafted ultrasmall gadolinium oxide nanoparticles (Bio-PAA-Gd2O3 NPs) were synthesized for enhanced tumor imaging using Bio as a tumor-targeting ligand. The average particle diameter of Gd2O3 NPs was 2.1 nm. The Bio-PAA-Gd2O3 NPs exhibited excellent colloidal stability (i. e., no precipitation) and a high longitudinal water proton spin relaxivity (r1) of 23.8 s−1 mM−1 (r2/r1=1.6 and r2=transverse water proton spin relaxivity), which was ∼6 times higher than those of commercial Gd-chelated magnetic resonance imaging (MRI) contrast agents. Cytotoxicity tests using two cell lines showed that the Bio-PAA-Gd2O3 NPs were almost non-toxic up to the measured concentration of 500 μM Gd. The enhanced tumor imaging of the Bio-PAA-Gd2O3 NPs was demonstrated through their higher positive contrasts and longer contrast retention at the tumor after intravenous injection in T1 MR images, compared with those of the control PAA-Gd2O3 NPs.",

keywords = "biotin, magnetic resonance imaging, nanoparticles, tumor models, tumor targeting",

author = "Ahmad, {Mohammad Yaseen} and Shuwen Liu and Tirusew Tegafaw and {Al Saidi}, {Abdullah Khamis Ali} and Dejun Zhao and Ying Liu and Sangyeol Lee and Seungho Kim and Yang, {So Hyeon} and Hwang, {Dong Wook} and Ahrum Baek and Jung, {Jae Chang} and Nam, {Sung Wook} and Chae, {Kwon Seok} and Yongmin Chang and Lee, {Gang Ho}",

note = "Publisher Copyright: {\textcopyright} 2023 Wiley-VCH GmbH.",

year = "2023",

month = sep,

day = "25",

doi = "10.1002/ejic.202300430",

language = "English",

volume = "26",

journal = "European Journal of Inorganic Chemistry",

issn = "1434-1948",

publisher = "Wiley-VCH Verlag",

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Ahmad, MY, Liu, S, Tegafaw, T, Al Saidi, AKA, Zhao, D, Liu, Y, Lee, S, Kim, S, Yang, SH, Hwang, DW, Baek, A, Jung, JC , Nam, SW , Chae, KS , Chang, Y & Lee, GH 2023, 'Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging', European Journal of Inorganic Chemistry, vol. 26, no. 27, e202300430. https://doi.org/10.1002/ejic.202300430

TY - JOUR

T1 - Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging

AU - Ahmad, Mohammad Yaseen

AU - Liu, Shuwen

AU - Tegafaw, Tirusew

AU - Al Saidi, Abdullah Khamis Ali

AU - Zhao, Dejun

AU - Liu, Ying

AU - Lee, Sangyeol

AU - Kim, Seungho

AU - Yang, So Hyeon

AU - Hwang, Dong Wook

AU - Baek, Ahrum

AU - Jung, Jae Chang

AU - Nam, Sung Wook

AU - Chae, Kwon Seok

AU - Chang, Yongmin

AU - Lee, Gang Ho

PY - 2023/9/25

Y1 - 2023/9/25

N2 - Herein, biotin (Bio)-conjugated poly(acrylic acid) (PAA)-grafted ultrasmall gadolinium oxide nanoparticles (Bio-PAA-Gd2O3 NPs) were synthesized for enhanced tumor imaging using Bio as a tumor-targeting ligand. The average particle diameter of Gd2O3 NPs was 2.1 nm. The Bio-PAA-Gd2O3 NPs exhibited excellent colloidal stability (i. e., no precipitation) and a high longitudinal water proton spin relaxivity (r1) of 23.8 s−1 mM−1 (r2/r1=1.6 and r2=transverse water proton spin relaxivity), which was ∼6 times higher than those of commercial Gd-chelated magnetic resonance imaging (MRI) contrast agents. Cytotoxicity tests using two cell lines showed that the Bio-PAA-Gd2O3 NPs were almost non-toxic up to the measured concentration of 500 μM Gd. The enhanced tumor imaging of the Bio-PAA-Gd2O3 NPs was demonstrated through their higher positive contrasts and longer contrast retention at the tumor after intravenous injection in T1 MR images, compared with those of the control PAA-Gd2O3 NPs.

AB - Herein, biotin (Bio)-conjugated poly(acrylic acid) (PAA)-grafted ultrasmall gadolinium oxide nanoparticles (Bio-PAA-Gd2O3 NPs) were synthesized for enhanced tumor imaging using Bio as a tumor-targeting ligand. The average particle diameter of Gd2O3 NPs was 2.1 nm. The Bio-PAA-Gd2O3 NPs exhibited excellent colloidal stability (i. e., no precipitation) and a high longitudinal water proton spin relaxivity (r1) of 23.8 s−1 mM−1 (r2/r1=1.6 and r2=transverse water proton spin relaxivity), which was ∼6 times higher than those of commercial Gd-chelated magnetic resonance imaging (MRI) contrast agents. Cytotoxicity tests using two cell lines showed that the Bio-PAA-Gd2O3 NPs were almost non-toxic up to the measured concentration of 500 μM Gd. The enhanced tumor imaging of the Bio-PAA-Gd2O3 NPs was demonstrated through their higher positive contrasts and longer contrast retention at the tumor after intravenous injection in T1 MR images, compared with those of the control PAA-Gd2O3 NPs.

KW - biotin

KW - magnetic resonance imaging

KW - nanoparticles

KW - tumor models

KW - tumor targeting

UR - http://www.scopus.com/inward/record.url?scp=85165623974&partnerID=8YFLogxK

U2 - 10.1002/ejic.202300430

DO - 10.1002/ejic.202300430

M3 - Article

AN - SCOPUS:85165623974

SN - 1434-1948

VL - 26

JO - European Journal of Inorganic Chemistry

JF - European Journal of Inorganic Chemistry

IS - 27

M1 - e202300430

ER -

Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging

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Keywords

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