Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging

Mohammad Yaseen Ahmad; Shuwen Liu; Tirusew Tegafaw; Abdullah Khamis Ali Al Saidi; Dejun Zhao; Ying Liu; Sangyeol Lee; Seungho Kim; So Hyeon Yang; Dong Wook Hwang; Ahrum Baek; Jae Chang Jung; Sung Wook Nam; Kwon Seok Chae; Yongmin Chang; Gang Ho Lee

doi:10.1002/ejic.202300430

Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging

Mohammad Yaseen Ahmad
, Shuwen Liu
, Tirusew Tegafaw
, Abdullah Khamis Ali Al Saidi
, Dejun Zhao
, Ying Liu
, Sangyeol Lee
, Seungho Kim
, So Hyeon Yang
, Dong Wook Hwang
, Ahrum Baek
, Jae Chang Jung
, Sung Wook Nam
, Kwon Seok Chae
, Yongmin Chang
, Gang Ho Lee

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Herein, biotin (Bio)-conjugated poly(acrylic acid) (PAA)-grafted ultrasmall gadolinium oxide nanoparticles (Bio-PAA-Gd₂O₃ NPs) were synthesized for enhanced tumor imaging using Bio as a tumor-targeting ligand. The average particle diameter of Gd₂O₃ NPs was 2.1 nm. The Bio-PAA-Gd₂O₃ NPs exhibited excellent colloidal stability (i. e., no precipitation) and a high longitudinal water proton spin relaxivity (r₁) of 23.8 s⁻¹ mM⁻¹ (r₂/r₁=1.6 and r₂=transverse water proton spin relaxivity), which was ∼6 times higher than those of commercial Gd-chelated magnetic resonance imaging (MRI) contrast agents. Cytotoxicity tests using two cell lines showed that the Bio-PAA-Gd₂O₃ NPs were almost non-toxic up to the measured concentration of 500 μM Gd. The enhanced tumor imaging of the Bio-PAA-Gd₂O₃ NPs was demonstrated through their higher positive contrasts and longer contrast retention at the tumor after intravenous injection in T₁ MR images, compared with those of the control PAA-Gd₂O₃ NPs.

Original language	English
Article number	e202300430
Journal	European Journal of Inorganic Chemistry
Volume	26
Issue number	27
DOIs	https://doi.org/10.1002/ejic.202300430
State	Published - 25 Sep 2023

Keywords

biotin
magnetic resonance imaging
nanoparticles
tumor models
tumor targeting

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10.1002/ejic.202300430

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Ahmad, M. Y., Liu, S., Tegafaw, T., Al Saidi, A. K. A., Zhao, D., Liu, Y., Lee, S., Kim, S., Yang, S. H., Hwang, D. W., Baek, A., Jung, J. C., Nam, S. W., Chae, K. S., Chang, Y., & Lee, G. H. (2023). Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging. European Journal of Inorganic Chemistry, 26(27), Article e202300430. https://doi.org/10.1002/ejic.202300430

@article{f71e580477be480781b56998ac885986,

title = "Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging",

abstract = "Herein, biotin (Bio)-conjugated poly(acrylic acid) (PAA)-grafted ultrasmall gadolinium oxide nanoparticles (Bio-PAA-Gd2O3 NPs) were synthesized for enhanced tumor imaging using Bio as a tumor-targeting ligand. The average particle diameter of Gd2O3 NPs was 2.1 nm. The Bio-PAA-Gd2O3 NPs exhibited excellent colloidal stability (i. e., no precipitation) and a high longitudinal water proton spin relaxivity (r1) of 23.8 s−1 mM−1 (r2/r1=1.6 and r2=transverse water proton spin relaxivity), which was ∼6 times higher than those of commercial Gd-chelated magnetic resonance imaging (MRI) contrast agents. Cytotoxicity tests using two cell lines showed that the Bio-PAA-Gd2O3 NPs were almost non-toxic up to the measured concentration of 500 μM Gd. The enhanced tumor imaging of the Bio-PAA-Gd2O3 NPs was demonstrated through their higher positive contrasts and longer contrast retention at the tumor after intravenous injection in T1 MR images, compared with those of the control PAA-Gd2O3 NPs.",

keywords = "biotin, magnetic resonance imaging, nanoparticles, tumor models, tumor targeting",

author = "Ahmad, \{Mohammad Yaseen\} and Shuwen Liu and Tirusew Tegafaw and \{Al Saidi\}, \{Abdullah Khamis Ali\} and Dejun Zhao and Ying Liu and Sangyeol Lee and Seungho Kim and Yang, \{So Hyeon\} and Hwang, \{Dong Wook\} and Ahrum Baek and Jung, \{Jae Chang\} and Nam, \{Sung Wook\} and Chae, \{Kwon Seok\} and Yongmin Chang and Lee, \{Gang Ho\}",

note = "Publisher Copyright: {\textcopyright} 2023 Wiley-VCH GmbH.",

year = "2023",

month = sep,

day = "25",

doi = "10.1002/ejic.202300430",

language = "English",

volume = "26",

journal = "European Journal of Inorganic Chemistry",

issn = "1434-1948",

publisher = "Wiley-VCH Verlag",

number = "27",

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Ahmad, MY, Liu, S, Tegafaw, T, Al Saidi, AKA, Zhao, D, Liu, Y, Lee, S, Kim, S, Yang, SH, Hwang, DW, Baek, A, Jung, JC , Nam, SW , Chae, KS , Chang, Y & Lee, GH 2023, 'Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging', European Journal of Inorganic Chemistry, vol. 26, no. 27, e202300430. https://doi.org/10.1002/ejic.202300430

TY - JOUR

T1 - Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging

AU - Ahmad, Mohammad Yaseen

AU - Liu, Shuwen

AU - Tegafaw, Tirusew

AU - Al Saidi, Abdullah Khamis Ali

AU - Zhao, Dejun

AU - Liu, Ying

AU - Lee, Sangyeol

AU - Kim, Seungho

AU - Yang, So Hyeon

AU - Hwang, Dong Wook

AU - Baek, Ahrum

AU - Jung, Jae Chang

AU - Nam, Sung Wook

AU - Chae, Kwon Seok

AU - Chang, Yongmin

AU - Lee, Gang Ho

PY - 2023/9/25

Y1 - 2023/9/25

N2 - Herein, biotin (Bio)-conjugated poly(acrylic acid) (PAA)-grafted ultrasmall gadolinium oxide nanoparticles (Bio-PAA-Gd2O3 NPs) were synthesized for enhanced tumor imaging using Bio as a tumor-targeting ligand. The average particle diameter of Gd2O3 NPs was 2.1 nm. The Bio-PAA-Gd2O3 NPs exhibited excellent colloidal stability (i. e., no precipitation) and a high longitudinal water proton spin relaxivity (r1) of 23.8 s−1 mM−1 (r2/r1=1.6 and r2=transverse water proton spin relaxivity), which was ∼6 times higher than those of commercial Gd-chelated magnetic resonance imaging (MRI) contrast agents. Cytotoxicity tests using two cell lines showed that the Bio-PAA-Gd2O3 NPs were almost non-toxic up to the measured concentration of 500 μM Gd. The enhanced tumor imaging of the Bio-PAA-Gd2O3 NPs was demonstrated through their higher positive contrasts and longer contrast retention at the tumor after intravenous injection in T1 MR images, compared with those of the control PAA-Gd2O3 NPs.

AB - Herein, biotin (Bio)-conjugated poly(acrylic acid) (PAA)-grafted ultrasmall gadolinium oxide nanoparticles (Bio-PAA-Gd2O3 NPs) were synthesized for enhanced tumor imaging using Bio as a tumor-targeting ligand. The average particle diameter of Gd2O3 NPs was 2.1 nm. The Bio-PAA-Gd2O3 NPs exhibited excellent colloidal stability (i. e., no precipitation) and a high longitudinal water proton spin relaxivity (r1) of 23.8 s−1 mM−1 (r2/r1=1.6 and r2=transverse water proton spin relaxivity), which was ∼6 times higher than those of commercial Gd-chelated magnetic resonance imaging (MRI) contrast agents. Cytotoxicity tests using two cell lines showed that the Bio-PAA-Gd2O3 NPs were almost non-toxic up to the measured concentration of 500 μM Gd. The enhanced tumor imaging of the Bio-PAA-Gd2O3 NPs was demonstrated through their higher positive contrasts and longer contrast retention at the tumor after intravenous injection in T1 MR images, compared with those of the control PAA-Gd2O3 NPs.

KW - biotin

KW - magnetic resonance imaging

KW - nanoparticles

KW - tumor models

KW - tumor targeting

UR - https://www.scopus.com/pages/publications/85165623974

U2 - 10.1002/ejic.202300430

DO - 10.1002/ejic.202300430

M3 - Article

AN - SCOPUS:85165623974

SN - 1434-1948

VL - 26

JO - European Journal of Inorganic Chemistry

JF - European Journal of Inorganic Chemistry

IS - 27

M1 - e202300430

ER -

Biotin-Conjugated Poly(Acrylic Acid)-Grafted Ultrasmall Gadolinium Oxide Nanoparticles for Enhanced Tumor Imaging

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