Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja

Weihong Wang; Hiyoung Kim; Rahul S. Patil; Awadut G. Giri; Dong Hwan Won; Dongyup Hahn; Youjung Sung; Jusung Lee; Hyukjae Choi; Sang Jip Nam; Heonjoong Kang

doi:10.1016/j.bmcl.2016.12.016

Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja

Weihong Wang, Hiyoung Kim, Rahul S. Patil, Awadut G. Giri, Dong Hwan Won, Dongyup Hahn, Youjung Sung, Jusung Lee, Hyukjae Choi, Sang Jip Nam, Heonjoong Kang

School of Food Science & Biotechnology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J–M, 1, 3–5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.

Original language	English
Pages (from-to)	574-577
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2016.12.016
State	Published - 2017

Keywords

Antibacterial activity
Pseudodistoma antinboja
Tunicate

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10.1016/j.bmcl.2016.12.016

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title = "Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja",

abstract = "Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J–M, 1, 3–5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.",

keywords = "Antibacterial activity, Pseudodistoma antinboja, Tunicate",

author = "Weihong Wang and Hiyoung Kim and Patil, {Rahul S.} and Giri, {Awadut G.} and Won, {Dong Hwan} and Dongyup Hahn and Youjung Sung and Jusung Lee and Hyukjae Choi and Nam, {Sang Jip} and Heonjoong Kang",

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year = "2017",

doi = "10.1016/j.bmcl.2016.12.016",

language = "English",

volume = "27",

pages = "574--577",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja

AU - Wang, Weihong

AU - Kim, Hiyoung

AU - Patil, Rahul S.

AU - Giri, Awadut G.

AU - Won, Dong Hwan

AU - Hahn, Dongyup

AU - Sung, Youjung

AU - Lee, Jusung

AU - Choi, Hyukjae

AU - Nam, Sang Jip

AU - Kang, Heonjoong

PY - 2017

Y1 - 2017

N2 - Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J–M, 1, 3–5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.

AB - Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J–M, 1, 3–5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.

KW - Antibacterial activity

KW - Pseudodistoma antinboja

KW - Tunicate

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U2 - 10.1016/j.bmcl.2016.12.016

DO - 10.1016/j.bmcl.2016.12.016

M3 - Article

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AN - SCOPUS:85009160511

SN - 0960-894X

VL - 27

SP - 574

EP - 577

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 3

ER -

Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja

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Keywords

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