Caffeoyl glucosides from Nandina domestica inhibit LPS-induced endothelial inflammatory responses

Roshan R. Kulkarni; Wonhwa Lee; Tae Su Jang; Jung In Lee; Soyoung Kwak; Mi Seon Park; Hyun Shik Lee; Jong Sup Bae; Min Kyun Na

doi:10.1016/j.bmcl.2015.09.031

Caffeoyl glucosides from Nandina domestica inhibit LPS-induced endothelial inflammatory responses

Roshan R. Kulkarni
, Wonhwa Lee
, Tae Su Jang
, Jung In Lee
, Soyoung Kwak
, Mi Seon Park
, Hyun Shik Lee
, Jong Sup Bae
, Min Kyun Na

Chungnam National University
Kyungpook National University
Seoul National University
National Fisheries Research and Development Institute

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Endothelial dysfunction is a key pathological feature of many inflammatory diseases, including sepsis. In the present study, a new caffeoyl glucoside (1) and two known caffeoylated compounds (2 and 3) were isolated from the fruits of Nandina domestica Thunb. (Berberidaceae). The compounds were investigated for their effects against lipopolysaccharide (LPS)-mediated endothelial inflammatory responses. At 20 μM, 1 and 2 inhibited LPS-induced hyperpermeability, adhesion, and migration of leukocytes across a human endothelial cell monolayer in a dose-dependent manner suggesting that 1 and 2 may serve as potential scaffolds for the development of therapeutic agents to treat vascular inflammatory disorders.

Original language	English
Pages (from-to)	5367-5371
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2015.09.031
State	Published - 15 Nov 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Berberidaceae
Caffeoyl glucosides
Nandina domestica Thunb.
Vascular inflammatory disorders

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10.1016/j.bmcl.2015.09.031

Cite this

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title = "Caffeoyl glucosides from Nandina domestica inhibit LPS-induced endothelial inflammatory responses",

abstract = "Endothelial dysfunction is a key pathological feature of many inflammatory diseases, including sepsis. In the present study, a new caffeoyl glucoside (1) and two known caffeoylated compounds (2 and 3) were isolated from the fruits of Nandina domestica Thunb. (Berberidaceae). The compounds were investigated for their effects against lipopolysaccharide (LPS)-mediated endothelial inflammatory responses. At 20 μM, 1 and 2 inhibited LPS-induced hyperpermeability, adhesion, and migration of leukocytes across a human endothelial cell monolayer in a dose-dependent manner suggesting that 1 and 2 may serve as potential scaffolds for the development of therapeutic agents to treat vascular inflammatory disorders.",

keywords = "Berberidaceae, Caffeoyl glucosides, Nandina domestica Thunb., Vascular inflammatory disorders",

author = "Kulkarni, \{Roshan R.\} and Wonhwa Lee and Jang, \{Tae Su\} and Lee, \{Jung In\} and Soyoung Kwak and Park, \{Mi Seon\} and Lee, \{Hyun Shik\} and Bae, \{Jong Sup\} and Na, \{Min Kyun\}",

year = "2015",

month = nov,

day = "15",

doi = "10.1016/j.bmcl.2015.09.031",

language = "English",

volume = "25",

pages = "5367--5371",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "22",

}

TY - JOUR

T1 - Caffeoyl glucosides from Nandina domestica inhibit LPS-induced endothelial inflammatory responses

AU - Kulkarni, Roshan R.

AU - Lee, Wonhwa

AU - Jang, Tae Su

AU - Lee, Jung In

AU - Kwak, Soyoung

AU - Park, Mi Seon

AU - Lee, Hyun Shik

AU - Bae, Jong Sup

AU - Na, Min Kyun

PY - 2015/11/15

Y1 - 2015/11/15

N2 - Endothelial dysfunction is a key pathological feature of many inflammatory diseases, including sepsis. In the present study, a new caffeoyl glucoside (1) and two known caffeoylated compounds (2 and 3) were isolated from the fruits of Nandina domestica Thunb. (Berberidaceae). The compounds were investigated for their effects against lipopolysaccharide (LPS)-mediated endothelial inflammatory responses. At 20 μM, 1 and 2 inhibited LPS-induced hyperpermeability, adhesion, and migration of leukocytes across a human endothelial cell monolayer in a dose-dependent manner suggesting that 1 and 2 may serve as potential scaffolds for the development of therapeutic agents to treat vascular inflammatory disorders.

AB - Endothelial dysfunction is a key pathological feature of many inflammatory diseases, including sepsis. In the present study, a new caffeoyl glucoside (1) and two known caffeoylated compounds (2 and 3) were isolated from the fruits of Nandina domestica Thunb. (Berberidaceae). The compounds were investigated for their effects against lipopolysaccharide (LPS)-mediated endothelial inflammatory responses. At 20 μM, 1 and 2 inhibited LPS-induced hyperpermeability, adhesion, and migration of leukocytes across a human endothelial cell monolayer in a dose-dependent manner suggesting that 1 and 2 may serve as potential scaffolds for the development of therapeutic agents to treat vascular inflammatory disorders.

KW - Berberidaceae

KW - Caffeoyl glucosides

KW - Nandina domestica Thunb.

KW - Vascular inflammatory disorders

UR - https://www.scopus.com/pages/publications/84945950679

U2 - 10.1016/j.bmcl.2015.09.031

DO - 10.1016/j.bmcl.2015.09.031

M3 - Article

C2 - 26410076

AN - SCOPUS:84945950679

SN - 0960-894X

VL - 25

SP - 5367

EP - 5371

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 22

ER -

Caffeoyl glucosides from Nandina domestica inhibit LPS-induced endothelial inflammatory responses

Abstract

UN SDGs

Keywords

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