TY - JOUR
T1 - Calcium-Calmodulin-Calcineurin Signaling
T2 - A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens
AU - Park, Hee Soo
AU - Lee, Soo Chan
AU - Cardenas, Maria E.
AU - Heitman, Joseph
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/10/9
Y1 - 2019/10/9
N2 - Calcium is an abundant intracellular ion, and calcium homeostasis plays crucial roles in several cellular processes. The calcineurin signaling cascade is one of the major pathways governed by intracellular calcium. Calcineurin, a conserved protein from yeast to humans, is a calcium-calmodulin-dependent serine-threonine-specific phosphatase that orchestrates cellular stress responses. In eukaryotic microbial pathogens, calcineurin controls essential virulence pathways, such as the ability to grow at host temperature, morphogenesis to enable invasive hyphal growth, drug tolerance and resistance, cell wall integrity, and sexual development. Therefore, the calcineurin cascade is an attractive target in drug development against eukaryotic pathogens. In the present review, we summarize and discuss the current knowledge on the roles of calcineurin in eukaryotic microbial pathogens, focusing on fungi and parasitic protists.
AB - Calcium is an abundant intracellular ion, and calcium homeostasis plays crucial roles in several cellular processes. The calcineurin signaling cascade is one of the major pathways governed by intracellular calcium. Calcineurin, a conserved protein from yeast to humans, is a calcium-calmodulin-dependent serine-threonine-specific phosphatase that orchestrates cellular stress responses. In eukaryotic microbial pathogens, calcineurin controls essential virulence pathways, such as the ability to grow at host temperature, morphogenesis to enable invasive hyphal growth, drug tolerance and resistance, cell wall integrity, and sexual development. Therefore, the calcineurin cascade is an attractive target in drug development against eukaryotic pathogens. In the present review, we summarize and discuss the current knowledge on the roles of calcineurin in eukaryotic microbial pathogens, focusing on fungi and parasitic protists.
UR - http://www.scopus.com/inward/record.url?scp=85071299856&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2019.08.004
DO - 10.1016/j.chom.2019.08.004
M3 - Review article
C2 - 31600499
AN - SCOPUS:85071299856
SN - 1931-3128
VL - 26
SP - 453
EP - 462
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 4
ER -