Abstract
Background:: Cutaneous arteriovenous malformations (AVMs) of stage I may mimic port-wine stains (PWSs) clinicopathologically; therefore, it may be misdiagnosed and mistreated as being PWS. Objective:: To suggest the clinicopathological differential clues between early AVMs and PWSs. METHODS:: A set of 10 radiologically proven AVMs of stage I was selected in conjunction with a set of 10 age-/sex-matched PWSs as a control. Their clinical features, hematoxylin and eosin, CD31, and smooth muscle actin immunohistochemistry were then compared. Results:: Four pathological clues for differential diagnosis with statistical significance (P < 0.05) were found: the vessel density (CD31), presence of vascular luminal red blood cells, elongation and haphazard branching of vessels, and thickened vessel walls highlighted by smooth muscle actin. CONCLUSION:: Therefore, 4 differential clues with respect to stage I AVM and PWS in their earlier developmental stages have been proposed.
| Original language | English |
|---|---|
| Pages (from-to) | 523-528 |
| Number of pages | 6 |
| Journal | American Journal of Dermatopathology |
| Volume | 34 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jul 2012 |
Keywords
- arteriovenous malformation
- differential diagnosis
- histopathology
- portwine stain