Carbon-coated ultrasmall gadolinium oxide (Gd2O3@C) nanoparticles: Application to magnetic resonance imaging and fluorescence properties

Huan Yue; Shanti Marasini; Mohammad Yaseen Ahmad; Son Long Ho; Hyunsil Cha; Shuwen Liu; Yeong Ji Jang; Tirusew Tegafaw; Adibehalsadat Ghazanfari; Xu Miao; Kwon Seok Chae; Yongmin Chang; Gang Ho Lee

doi:10.1016/j.colsurfa.2019.124261

Carbon-coated ultrasmall gadolinium oxide (Gd₂O₃@C) nanoparticles: Application to magnetic resonance imaging and fluorescence properties

Huan Yue
, Shanti Marasini
, Mohammad Yaseen Ahmad
, Son Long Ho
, Hyunsil Cha
, Shuwen Liu
, Yeong Ji Jang
, Tirusew Tegafaw
, Adibehalsadat Ghazanfari
, Xu Miao
, Kwon Seok Chae
, Yongmin Chang
, Gang Ho Lee

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Carbon may be an ideal surface-coating material on nanoparticles (NPs) for biomedical applications because carbon is biocompatible, nearly chemically inert, and photoluminescent in the visible region. In this research, the carbon-coated ultrasmall gadolinium oxide (Gd₂O₃@C) core-shell NPs (core = Gd₂O₃; shell = carbon) were synthesized in aqueous solution using a simple method. The ultrasmall Gd₂O₃@C NPs (d_avg = 3.1 nm; a_avg = 18.9 nm) had excellent colloidal stability, very high r₁ value (16.26 s⁻¹ mM⁻¹; r₂/r₁ = 1.48), and exhibited photoluminescence in the visible region. In vivo positive (i.e., T₁) magnetic resonance images of high contrast indicated that the ultrasmall Gd₂O₃@C NPs should be a potential T₁ magnetic resonance imaging (MRI) contrast agent. Additionally, strong fluorescence in the visible region was observed due to carbon coating on the NP surfaces, indicating that the ultrasmall Gd₂O₃@C NPs are eligible for use as a dual-modal imaging agent.

Original language	English
Article number	124261
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	586
DOIs	https://doi.org/10.1016/j.colsurfa.2019.124261
State	Published - 5 Feb 2020

Keywords

Carbon coating
Core-Shell
Fluorescence properties
Magnetic resonance imaging
Ultrasmall GdO@C nanoparticle

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10.1016/j.colsurfa.2019.124261

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Yue, H., Marasini, S., Ahmad, M. Y., Ho, S. L., Cha, H., Liu, S., Jang, Y. J., Tegafaw, T., Ghazanfari, A., Miao, X., Chae, K. S., Chang, Y., & Lee, G. H. (2020). Carbon-coated ultrasmall gadolinium oxide (Gd₂O₃@C) nanoparticles: Application to magnetic resonance imaging and fluorescence properties. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 586, Article 124261. https://doi.org/10.1016/j.colsurfa.2019.124261

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title = "Carbon-coated ultrasmall gadolinium oxide (Gd2O3@C) nanoparticles: Application to magnetic resonance imaging and fluorescence properties",

abstract = "Carbon may be an ideal surface-coating material on nanoparticles (NPs) for biomedical applications because carbon is biocompatible, nearly chemically inert, and photoluminescent in the visible region. In this research, the carbon-coated ultrasmall gadolinium oxide (Gd2O3@C) core-shell NPs (core = Gd2O3; shell = carbon) were synthesized in aqueous solution using a simple method. The ultrasmall Gd2O3@C NPs (davg = 3.1 nm; aavg = 18.9 nm) had excellent colloidal stability, very high r1 value (16.26 s−1 mM−1; r2/r1 = 1.48), and exhibited photoluminescence in the visible region. In vivo positive (i.e., T1) magnetic resonance images of high contrast indicated that the ultrasmall Gd2O3@C NPs should be a potential T1 magnetic resonance imaging (MRI) contrast agent. Additionally, strong fluorescence in the visible region was observed due to carbon coating on the NP surfaces, indicating that the ultrasmall Gd2O3@C NPs are eligible for use as a dual-modal imaging agent.",

keywords = "Carbon coating, Core-Shell, Fluorescence properties, Magnetic resonance imaging, Ultrasmall GdO@C nanoparticle",

author = "Huan Yue and Shanti Marasini and Ahmad, \{Mohammad Yaseen\} and Ho, \{Son Long\} and Hyunsil Cha and Shuwen Liu and Jang, \{Yeong Ji\} and Tirusew Tegafaw and Adibehalsadat Ghazanfari and Xu Miao and Chae, \{Kwon Seok\} and Yongmin Chang and Lee, \{Gang Ho\}",

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year = "2020",

month = feb,

day = "5",

doi = "10.1016/j.colsurfa.2019.124261",

language = "English",

volume = "586",

journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",

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Yue, H, Marasini, S, Ahmad, MY, Ho, SL, Cha, H, Liu, S, Jang, YJ, Tegafaw, T, Ghazanfari, A, Miao, X, Chae, KS , Chang, Y & Lee, GH 2020, 'Carbon-coated ultrasmall gadolinium oxide (Gd₂O₃@C) nanoparticles: Application to magnetic resonance imaging and fluorescence properties', Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol. 586, 124261. https://doi.org/10.1016/j.colsurfa.2019.124261

TY - JOUR

T1 - Carbon-coated ultrasmall gadolinium oxide (Gd2O3@C) nanoparticles

T2 - Application to magnetic resonance imaging and fluorescence properties

AU - Yue, Huan

AU - Marasini, Shanti

AU - Ahmad, Mohammad Yaseen

AU - Ho, Son Long

AU - Cha, Hyunsil

AU - Liu, Shuwen

AU - Jang, Yeong Ji

AU - Tegafaw, Tirusew

AU - Ghazanfari, Adibehalsadat

AU - Miao, Xu

AU - Chae, Kwon Seok

AU - Chang, Yongmin

AU - Lee, Gang Ho

PY - 2020/2/5

Y1 - 2020/2/5

N2 - Carbon may be an ideal surface-coating material on nanoparticles (NPs) for biomedical applications because carbon is biocompatible, nearly chemically inert, and photoluminescent in the visible region. In this research, the carbon-coated ultrasmall gadolinium oxide (Gd2O3@C) core-shell NPs (core = Gd2O3; shell = carbon) were synthesized in aqueous solution using a simple method. The ultrasmall Gd2O3@C NPs (davg = 3.1 nm; aavg = 18.9 nm) had excellent colloidal stability, very high r1 value (16.26 s−1 mM−1; r2/r1 = 1.48), and exhibited photoluminescence in the visible region. In vivo positive (i.e., T1) magnetic resonance images of high contrast indicated that the ultrasmall Gd2O3@C NPs should be a potential T1 magnetic resonance imaging (MRI) contrast agent. Additionally, strong fluorescence in the visible region was observed due to carbon coating on the NP surfaces, indicating that the ultrasmall Gd2O3@C NPs are eligible for use as a dual-modal imaging agent.

AB - Carbon may be an ideal surface-coating material on nanoparticles (NPs) for biomedical applications because carbon is biocompatible, nearly chemically inert, and photoluminescent in the visible region. In this research, the carbon-coated ultrasmall gadolinium oxide (Gd2O3@C) core-shell NPs (core = Gd2O3; shell = carbon) were synthesized in aqueous solution using a simple method. The ultrasmall Gd2O3@C NPs (davg = 3.1 nm; aavg = 18.9 nm) had excellent colloidal stability, very high r1 value (16.26 s−1 mM−1; r2/r1 = 1.48), and exhibited photoluminescence in the visible region. In vivo positive (i.e., T1) magnetic resonance images of high contrast indicated that the ultrasmall Gd2O3@C NPs should be a potential T1 magnetic resonance imaging (MRI) contrast agent. Additionally, strong fluorescence in the visible region was observed due to carbon coating on the NP surfaces, indicating that the ultrasmall Gd2O3@C NPs are eligible for use as a dual-modal imaging agent.

KW - Carbon coating

KW - Core-Shell

KW - Fluorescence properties

KW - Magnetic resonance imaging

KW - Ultrasmall GdO@C nanoparticle

UR - https://www.scopus.com/pages/publications/85076516292

U2 - 10.1016/j.colsurfa.2019.124261

DO - 10.1016/j.colsurfa.2019.124261

M3 - Article

AN - SCOPUS:85076516292

SN - 0927-7757

VL - 586

JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects

JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects

M1 - 124261

ER -

Carbon-coated ultrasmall gadolinium oxide (Gd₂O₃@C) nanoparticles: Application to magnetic resonance imaging and fluorescence properties

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