Cassaine diterpene alkaloids from Erythrophleum fordii and their anti-angiogenic effect

Tran Manh Hung; To Dao Cuong; Jeong Ah Kim; Nara Tae; Jeong Hyung Lee; Byung Sun Min

doi:10.1016/j.bmcl.2013.11.048

Cassaine diterpene alkaloids from Erythrophleum fordii and their anti-angiogenic effect

Tran Manh Hung, To Dao Cuong, Jeong Ah Kim, Nara Tae, Jeong Hyung Lee, Byung Sun Min

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Angiogenesis plays a critical role in embryonic development and various physiological processes. However, excessive angiogenesis is associated with several pathological conditions including cancer. Angiogenesis is closely related to tumor growth, invasion and metastasis, and is considered a prime target for anticancer therapy. In this study, two new mono cassaine diterpenoid amides (1, 5) and four known compounds (2-4, 6) were isolated from the bark of Erythrophleum fordii (Leguminosae). Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. The effects of isolates on endothelial tube formation on Matrigel were investigated. Among them, compound 3 was found to have the most potent inhibitory effect on the capillary-like structure formation of human umbilical vein endothelial cells (HUVECs).

Original language	English
Pages (from-to)	168-172
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2013.11.048
State	Published - 1 Jan 2014

Keywords

Anti-angiogenesis
Cassaine diterpenoid amide
Erythrophleum fordii
Leguminosae

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2013.11.048

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title = "Cassaine diterpene alkaloids from Erythrophleum fordii and their anti-angiogenic effect",

abstract = "Angiogenesis plays a critical role in embryonic development and various physiological processes. However, excessive angiogenesis is associated with several pathological conditions including cancer. Angiogenesis is closely related to tumor growth, invasion and metastasis, and is considered a prime target for anticancer therapy. In this study, two new mono cassaine diterpenoid amides (1, 5) and four known compounds (2-4, 6) were isolated from the bark of Erythrophleum fordii (Leguminosae). Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. The effects of isolates on endothelial tube formation on Matrigel were investigated. Among them, compound 3 was found to have the most potent inhibitory effect on the capillary-like structure formation of human umbilical vein endothelial cells (HUVECs).",

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author = "Hung, {Tran Manh} and Cuong, {To Dao} and Kim, {Jeong Ah} and Nara Tae and Lee, {Jeong Hyung} and Min, {Byung Sun}",

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AU - Hung, Tran Manh

AU - Cuong, To Dao

AU - Kim, Jeong Ah

AU - Tae, Nara

AU - Lee, Jeong Hyung

AU - Min, Byung Sun

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Angiogenesis plays a critical role in embryonic development and various physiological processes. However, excessive angiogenesis is associated with several pathological conditions including cancer. Angiogenesis is closely related to tumor growth, invasion and metastasis, and is considered a prime target for anticancer therapy. In this study, two new mono cassaine diterpenoid amides (1, 5) and four known compounds (2-4, 6) were isolated from the bark of Erythrophleum fordii (Leguminosae). Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. The effects of isolates on endothelial tube formation on Matrigel were investigated. Among them, compound 3 was found to have the most potent inhibitory effect on the capillary-like structure formation of human umbilical vein endothelial cells (HUVECs).

AB - Angiogenesis plays a critical role in embryonic development and various physiological processes. However, excessive angiogenesis is associated with several pathological conditions including cancer. Angiogenesis is closely related to tumor growth, invasion and metastasis, and is considered a prime target for anticancer therapy. In this study, two new mono cassaine diterpenoid amides (1, 5) and four known compounds (2-4, 6) were isolated from the bark of Erythrophleum fordii (Leguminosae). Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. The effects of isolates on endothelial tube formation on Matrigel were investigated. Among them, compound 3 was found to have the most potent inhibitory effect on the capillary-like structure formation of human umbilical vein endothelial cells (HUVECs).

KW - Anti-angiogenesis

KW - Cassaine diterpenoid amide

KW - Erythrophleum fordii

KW - Leguminosae

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SN - 0960-894X

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IS - 1

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Cassaine diterpene alkaloids from Erythrophleum fordii and their anti-angiogenic effect

Abstract

Keywords

UN SDGs

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