TY - JOUR
T1 - Cellular Stress Responses against Coronavirus Infection
T2 - A Means of the Innate Antiviral Defense
AU - Yoo, Ji Seung
N1 - Publisher Copyright:
Copyright © 2024 by the authors.
PY - 2024/1/28
Y1 - 2024/1/28
N2 - Cellular stress responses are crucial for maintaining cellular homeostasis. Stress granules (SGs), activated by eIF2α kinases in response to various stimuli, play a pivotal role in dealing with diverse stress conditions. Viral infection, as one kind of cellular stress, triggers specific cellular programs aimed at overcoming virus-induced stresses. Recent studies have revealed that virus-derived stress responses are tightly linked to the host's antiviral innate immunity. Virus infection-induced SGs act as platforms for antiviral sensors, facilitating the initiation of protective antiviral responses called "antiviral stress granules" (avSGs). However, many viruses, including coronaviruses, have evolved strategies to suppress avSG formation, thereby counteracting the host's immune responses. This review discusses the intricate relationship between cellular stress responses and antiviral innate immunity, with a specific focus on coronaviruses. Furthermore, the diverse mechanisms employed by viruses to counteract avSGs are described.
AB - Cellular stress responses are crucial for maintaining cellular homeostasis. Stress granules (SGs), activated by eIF2α kinases in response to various stimuli, play a pivotal role in dealing with diverse stress conditions. Viral infection, as one kind of cellular stress, triggers specific cellular programs aimed at overcoming virus-induced stresses. Recent studies have revealed that virus-derived stress responses are tightly linked to the host's antiviral innate immunity. Virus infection-induced SGs act as platforms for antiviral sensors, facilitating the initiation of protective antiviral responses called "antiviral stress granules" (avSGs). However, many viruses, including coronaviruses, have evolved strategies to suppress avSG formation, thereby counteracting the host's immune responses. This review discusses the intricate relationship between cellular stress responses and antiviral innate immunity, with a specific focus on coronaviruses. Furthermore, the diverse mechanisms employed by viruses to counteract avSGs are described.
KW - Coronavirus
KW - Interferon
KW - RIG-I-like receptors
KW - antiviral stress granule
KW - toll-like receptors
KW - virus immune evasion
UR - http://www.scopus.com/inward/record.url?scp=85184344850&partnerID=8YFLogxK
U2 - 10.4014/jmb.2307.07038
DO - 10.4014/jmb.2307.07038
M3 - Review article
C2 - 37674398
AN - SCOPUS:85184344850
SN - 1017-7825
VL - 34
SP - 1
EP - 9
JO - Journal of Microbiology and Biotechnology
JF - Journal of Microbiology and Biotechnology
IS - 1
ER -