Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry

Gayathri Rajendran; Deepu Bhanu; Baladhandapani Aruchamy; Prasanna Ramani; Nanjan Pandurangan; Kondapa Naidu Bobba; Eun Jung Oh; Ho Yun Chung; Prakash Gangadaran; Byeong Cheol Ahn

doi:10.3390/ph15101250

Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry

Gayathri Rajendran, Deepu Bhanu, Baladhandapani Aruchamy, Prasanna Ramani, Nanjan Pandurangan, Kondapa Naidu Bobba, Eun Jung Oh, Ho Yun Chung, Prakash Gangadaran, Byeong Cheol Ahn

Department of Medicine

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior. The present review aims to summarize the structures from natural sources, synthesis methods, biological characteristics against infectious and non-infectious diseases, and uses of chalcones over the past decade, and their structure–activity relationship studies are detailed in depth. This critical review provides guidelines for the future design and synthesis of various chalcones. In addition, this could be highly supportive for medicinal chemists to develop more promising candidates for various infectious and non-infectious diseases.

Original language	English
Article number	1250
Journal	Pharmaceuticals
Volume	15
Issue number	10
DOIs	https://doi.org/10.3390/ph15101250
State	Published - Oct 2022

Keywords

Claisen–Schmidt condensation
chalcones
infectious diseases
natural sources
non-infectious diseases
structure–activity relationship

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ph15101250

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title = "Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry",

abstract = "Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior. The present review aims to summarize the structures from natural sources, synthesis methods, biological characteristics against infectious and non-infectious diseases, and uses of chalcones over the past decade, and their structure–activity relationship studies are detailed in depth. This critical review provides guidelines for the future design and synthesis of various chalcones. In addition, this could be highly supportive for medicinal chemists to develop more promising candidates for various infectious and non-infectious diseases.",

keywords = "Claisen–Schmidt condensation, chalcones, infectious diseases, natural sources, non-infectious diseases, structure–activity relationship",

author = "Gayathri Rajendran and Deepu Bhanu and Baladhandapani Aruchamy and Prasanna Ramani and Nanjan Pandurangan and Bobba, {Kondapa Naidu} and Oh, {Eun Jung} and Chung, {Ho Yun} and Prakash Gangadaran and Ahn, {Byeong Cheol}",

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doi = "10.3390/ph15101250",

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volume = "15",

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T2 - A Promising Bioactive Scaffold in Medicinal Chemistry

AU - Rajendran, Gayathri

AU - Bhanu, Deepu

AU - Aruchamy, Baladhandapani

AU - Ramani, Prasanna

AU - Pandurangan, Nanjan

AU - Bobba, Kondapa Naidu

AU - Oh, Eun Jung

AU - Chung, Ho Yun

AU - Gangadaran, Prakash

AU - Ahn, Byeong Cheol

PY - 2022/10

Y1 - 2022/10

N2 - Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior. The present review aims to summarize the structures from natural sources, synthesis methods, biological characteristics against infectious and non-infectious diseases, and uses of chalcones over the past decade, and their structure–activity relationship studies are detailed in depth. This critical review provides guidelines for the future design and synthesis of various chalcones. In addition, this could be highly supportive for medicinal chemists to develop more promising candidates for various infectious and non-infectious diseases.

AB - Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior. The present review aims to summarize the structures from natural sources, synthesis methods, biological characteristics against infectious and non-infectious diseases, and uses of chalcones over the past decade, and their structure–activity relationship studies are detailed in depth. This critical review provides guidelines for the future design and synthesis of various chalcones. In addition, this could be highly supportive for medicinal chemists to develop more promising candidates for various infectious and non-infectious diseases.

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KW - infectious diseases

KW - natural sources

KW - non-infectious diseases

KW - structure–activity relationship

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Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry

Abstract

Keywords

UN SDGs

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