Changes in pyridoxal kinase immunoreactivity in the gerbil hippocampus following spontaneous seizure

Tae Cheon Kang; Seung Kook Park; In Koo Hwang; Sung Jin An; Jae Hoon Bahn; Dae Won Kim; Soo Young Choi; Oh Shin Kwon; Nam In Baek; Hyeon Yong Lee; Moo Ho Won

doi:10.1016/S0006-8993(02)03566-7

Changes in pyridoxal kinase immunoreactivity in the gerbil hippocampus following spontaneous seizure

Tae Cheon Kang, Seung Kook Park, In Koo Hwang, Sung Jin An, Jae Hoon Bahn, Dae Won Kim, Soo Young Choi, Oh Shin Kwon, Nam In Baek, Hyeon Yong Lee, Moo Ho Won

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

To identify the roles of pyridoxal kinase (PLK) in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PLK expression in the gerbil hippocampus was conducted. PLK immunoreactivity in a pre-seizure group of seizure sensitive (SS) gerbils was more strongly detected than that in a seizure resistant (SR) group. The density of PLK immunoreactivity in a 30-min postictal group was significantly lower than that of a pre-seizure group. In a 12 h postictal group, PLK immunodensity recovered to pre-seizure level. The over-expression of PLK in the hippocampus of pre-seizure SS gerbils suggests that PLP play an important role in the modulation of GAD activity and GABA reuptake as mediated by membrane transporter via neurons.

Original language	English
Pages (from-to)	242-250
Number of pages	9
Journal	Brain Research
Volume	957
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(02)03566-7
State	Published - 13 Dec 2002

Keywords

Epileptogenesis
Gerbil
Hippocampus
Pyridoxal 5′-phosphate
Pyridoxal kinase
Seizure

Access to Document

10.1016/S0006-8993(02)03566-7

Cite this

@article{3199da4760024eb58a0f41b01c7a4c7c,

title = "Changes in pyridoxal kinase immunoreactivity in the gerbil hippocampus following spontaneous seizure",

abstract = "To identify the roles of pyridoxal kinase (PLK) in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PLK expression in the gerbil hippocampus was conducted. PLK immunoreactivity in a pre-seizure group of seizure sensitive (SS) gerbils was more strongly detected than that in a seizure resistant (SR) group. The density of PLK immunoreactivity in a 30-min postictal group was significantly lower than that of a pre-seizure group. In a 12 h postictal group, PLK immunodensity recovered to pre-seizure level. The over-expression of PLK in the hippocampus of pre-seizure SS gerbils suggests that PLP play an important role in the modulation of GAD activity and GABA reuptake as mediated by membrane transporter via neurons.",

keywords = "Epileptogenesis, Gerbil, Hippocampus, Pyridoxal 5′-phosphate, Pyridoxal kinase, Seizure",

author = "Kang, {Tae Cheon} and Park, {Seung Kook} and {Koo Hwang}, In and An, {Sung Jin} and {Hoon Bahn}, Jae and {Won Kim}, Dae and {Young Choi}, Soo and Kwon, {Oh Shin} and Baek, {Nam In} and {Yong Lee}, Hyeon and {Ho Won}, Moo",

year = "2002",

month = dec,

day = "13",

doi = "10.1016/S0006-8993(02)03566-7",

language = "English",

volume = "957",

pages = "242--250",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Changes in pyridoxal kinase immunoreactivity in the gerbil hippocampus following spontaneous seizure

AU - Kang, Tae Cheon

AU - Park, Seung Kook

AU - Koo Hwang, In

AU - An, Sung Jin

AU - Hoon Bahn, Jae

AU - Won Kim, Dae

AU - Young Choi, Soo

AU - Kwon, Oh Shin

AU - Baek, Nam In

AU - Yong Lee, Hyeon

AU - Ho Won, Moo

PY - 2002/12/13

Y1 - 2002/12/13

N2 - To identify the roles of pyridoxal kinase (PLK) in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PLK expression in the gerbil hippocampus was conducted. PLK immunoreactivity in a pre-seizure group of seizure sensitive (SS) gerbils was more strongly detected than that in a seizure resistant (SR) group. The density of PLK immunoreactivity in a 30-min postictal group was significantly lower than that of a pre-seizure group. In a 12 h postictal group, PLK immunodensity recovered to pre-seizure level. The over-expression of PLK in the hippocampus of pre-seizure SS gerbils suggests that PLP play an important role in the modulation of GAD activity and GABA reuptake as mediated by membrane transporter via neurons.

AB - To identify the roles of pyridoxal kinase (PLK) in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PLK expression in the gerbil hippocampus was conducted. PLK immunoreactivity in a pre-seizure group of seizure sensitive (SS) gerbils was more strongly detected than that in a seizure resistant (SR) group. The density of PLK immunoreactivity in a 30-min postictal group was significantly lower than that of a pre-seizure group. In a 12 h postictal group, PLK immunodensity recovered to pre-seizure level. The over-expression of PLK in the hippocampus of pre-seizure SS gerbils suggests that PLP play an important role in the modulation of GAD activity and GABA reuptake as mediated by membrane transporter via neurons.

KW - Epileptogenesis

KW - Gerbil

KW - Hippocampus

KW - Pyridoxal 5′-phosphate

KW - Pyridoxal kinase

KW - Seizure

UR - http://www.scopus.com/inward/record.url?scp=0037073591&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(02)03566-7

DO - 10.1016/S0006-8993(02)03566-7

M3 - Article

C2 - 12445966

AN - SCOPUS:0037073591

SN - 0006-8993

VL - 957

SP - 242

EP - 250

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Changes in pyridoxal kinase immunoreactivity in the gerbil hippocampus following spontaneous seizure

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this