Changes in the α2-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain

Hee Jung Cho; Dong Sun Kim; Nam Hyuk Lee; Jeong Ki Kim; Kyung Mi Lee; Keum Su Han; Young Nim Kang; Kwang Jin Kim

doi:10.1097/00001756-199709290-00022

Changes in the α₂-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain

Hee Jung Cho, Dong Sun Kim, Nam Hyuk Lee, Jeong Ki Kim, Kyung Mi Lee, Keum Su Han, Young Nim Kang, Kwang Jin Kim

Department of Medicine

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

WE examined changes in expression of genes coding for α₂-AR subtypes in the dorsal root ganglion (DRG) in a rat model (spinal nerve ligation) of neuropathic pain. The present study demonstrates that the majority of DRG neurons express α₂C-AR mRNA and a small proportion of neurons express α₂A-AR mRNA, while few neurons express α₂B-AR mRNA in non-operated animals. In addition, α₂C- and α₂A mRNA levels in the DRG showed a significant decrease and increase, respectively in ligated animals. These findings suggest that α₂A- and α₂C-ARs in the DRG may play an important role in generating sympathetically maintained neuropathic pain.

Original language	English
Pages (from-to)	3119-3122
Number of pages	4
Journal	NeuroReport
Volume	8
Issue number	14
DOIs	https://doi.org/10.1097/00001756-199709290-00022
State	Published - 1997

Keywords

Dorsal root ganglion
Gene expression
In situ hybridization
Neuropathic pain
Reverse transcriptase-polymerase chain reaction
α-adrenergic receptor

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10.1097/00001756-199709290-00022

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title = "Changes in the α2-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain",

abstract = "WE examined changes in expression of genes coding for α2-AR subtypes in the dorsal root ganglion (DRG) in a rat model (spinal nerve ligation) of neuropathic pain. The present study demonstrates that the majority of DRG neurons express α2C-AR mRNA and a small proportion of neurons express α2A-AR mRNA, while few neurons express α2B-AR mRNA in non-operated animals. In addition, α2C- and α2A mRNA levels in the DRG showed a significant decrease and increase, respectively in ligated animals. These findings suggest that α2A- and α2C-ARs in the DRG may play an important role in generating sympathetically maintained neuropathic pain.",

keywords = "Dorsal root ganglion, Gene expression, In situ hybridization, Neuropathic pain, Reverse transcriptase-polymerase chain reaction, α-adrenergic receptor",

author = "Cho, \{Hee Jung\} and Kim, \{Dong Sun\} and Lee, \{Nam Hyuk\} and Kim, \{Jeong Ki\} and Lee, \{Kyung Mi\} and Han, \{Keum Su\} and Kang, \{Young Nim\} and Kim, \{Kwang Jin\}",

year = "1997",

doi = "10.1097/00001756-199709290-00022",

language = "English",

volume = "8",

pages = "3119--3122",

journal = "NeuroReport",

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T1 - Changes in the α2-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain

AU - Cho, Hee Jung

AU - Kim, Dong Sun

AU - Lee, Nam Hyuk

AU - Kim, Jeong Ki

AU - Lee, Kyung Mi

AU - Han, Keum Su

AU - Kang, Young Nim

AU - Kim, Kwang Jin

PY - 1997

Y1 - 1997

N2 - WE examined changes in expression of genes coding for α2-AR subtypes in the dorsal root ganglion (DRG) in a rat model (spinal nerve ligation) of neuropathic pain. The present study demonstrates that the majority of DRG neurons express α2C-AR mRNA and a small proportion of neurons express α2A-AR mRNA, while few neurons express α2B-AR mRNA in non-operated animals. In addition, α2C- and α2A mRNA levels in the DRG showed a significant decrease and increase, respectively in ligated animals. These findings suggest that α2A- and α2C-ARs in the DRG may play an important role in generating sympathetically maintained neuropathic pain.

AB - WE examined changes in expression of genes coding for α2-AR subtypes in the dorsal root ganglion (DRG) in a rat model (spinal nerve ligation) of neuropathic pain. The present study demonstrates that the majority of DRG neurons express α2C-AR mRNA and a small proportion of neurons express α2A-AR mRNA, while few neurons express α2B-AR mRNA in non-operated animals. In addition, α2C- and α2A mRNA levels in the DRG showed a significant decrease and increase, respectively in ligated animals. These findings suggest that α2A- and α2C-ARs in the DRG may play an important role in generating sympathetically maintained neuropathic pain.

KW - Dorsal root ganglion

KW - Gene expression

KW - In situ hybridization

KW - Neuropathic pain

KW - Reverse transcriptase-polymerase chain reaction

KW - α-adrenergic receptor

UR - https://www.scopus.com/pages/publications/0030768057

U2 - 10.1097/00001756-199709290-00022

DO - 10.1097/00001756-199709290-00022

M3 - Article

C2 - 9331925

AN - SCOPUS:0030768057

SN - 0959-4965

VL - 8

SP - 3119

EP - 3122

JO - NeuroReport

JF - NeuroReport

IS - 14

ER -

Changes in the α₂-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain

Abstract

Keywords

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