Changes in the α2-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain

Hee Jung Cho; Dong Sun Kim; Nam Hyuk Lee; Jeong Ki Kim; Kyung Mi Lee; Keum Su Han; Young Nim Kang; Kwang Jin Kim

doi:10.1097/00001756-199709290-00022

Changes in the α₂-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain

Hee Jung Cho
, Dong Sun Kim
, Nam Hyuk Lee
, Jeong Ki Kim
, Kyung Mi Lee
, Keum Su Han
, Young Nim Kang
, Kwang Jin Kim

Department of Medicine

Kyungpook National University
Chungnam National University

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

WE examined changes in expression of genes coding for α₂-AR subtypes in the dorsal root ganglion (DRG) in a rat model (spinal nerve ligation) of neuropathic pain. The present study demonstrates that the majority of DRG neurons express α₂C-AR mRNA and a small proportion of neurons express α₂A-AR mRNA, while few neurons express α₂B-AR mRNA in non-operated animals. In addition, α₂C- and α₂A mRNA levels in the DRG showed a significant decrease and increase, respectively in ligated animals. These findings suggest that α₂A- and α₂C-ARs in the DRG may play an important role in generating sympathetically maintained neuropathic pain.

Original language	English
Pages (from-to)	3119-3122
Number of pages	4
Journal	NeuroReport
Volume	8
Issue number	14
DOIs	https://doi.org/10.1097/00001756-199709290-00022
State	Published - 1997

Keywords

Dorsal root ganglion
Gene expression
In situ hybridization
Neuropathic pain
Reverse transcriptase-polymerase chain reaction
α-adrenergic receptor

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10.1097/00001756-199709290-00022

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title = "Changes in the α2-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain",

abstract = "WE examined changes in expression of genes coding for α2-AR subtypes in the dorsal root ganglion (DRG) in a rat model (spinal nerve ligation) of neuropathic pain. The present study demonstrates that the majority of DRG neurons express α2C-AR mRNA and a small proportion of neurons express α2A-AR mRNA, while few neurons express α2B-AR mRNA in non-operated animals. In addition, α2C- and α2A mRNA levels in the DRG showed a significant decrease and increase, respectively in ligated animals. These findings suggest that α2A- and α2C-ARs in the DRG may play an important role in generating sympathetically maintained neuropathic pain.",

keywords = "Dorsal root ganglion, Gene expression, In situ hybridization, Neuropathic pain, Reverse transcriptase-polymerase chain reaction, α-adrenergic receptor",

author = "Cho, \{Hee Jung\} and Kim, \{Dong Sun\} and Lee, \{Nam Hyuk\} and Kim, \{Jeong Ki\} and Lee, \{Kyung Mi\} and Han, \{Keum Su\} and Kang, \{Young Nim\} and Kim, \{Kwang Jin\}",

year = "1997",

doi = "10.1097/00001756-199709290-00022",

language = "English",

volume = "8",

pages = "3119--3122",

journal = "NeuroReport",

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T1 - Changes in the α2-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain

AU - Cho, Hee Jung

AU - Kim, Dong Sun

AU - Lee, Nam Hyuk

AU - Kim, Jeong Ki

AU - Lee, Kyung Mi

AU - Han, Keum Su

AU - Kang, Young Nim

AU - Kim, Kwang Jin

PY - 1997

Y1 - 1997

N2 - WE examined changes in expression of genes coding for α2-AR subtypes in the dorsal root ganglion (DRG) in a rat model (spinal nerve ligation) of neuropathic pain. The present study demonstrates that the majority of DRG neurons express α2C-AR mRNA and a small proportion of neurons express α2A-AR mRNA, while few neurons express α2B-AR mRNA in non-operated animals. In addition, α2C- and α2A mRNA levels in the DRG showed a significant decrease and increase, respectively in ligated animals. These findings suggest that α2A- and α2C-ARs in the DRG may play an important role in generating sympathetically maintained neuropathic pain.

AB - WE examined changes in expression of genes coding for α2-AR subtypes in the dorsal root ganglion (DRG) in a rat model (spinal nerve ligation) of neuropathic pain. The present study demonstrates that the majority of DRG neurons express α2C-AR mRNA and a small proportion of neurons express α2A-AR mRNA, while few neurons express α2B-AR mRNA in non-operated animals. In addition, α2C- and α2A mRNA levels in the DRG showed a significant decrease and increase, respectively in ligated animals. These findings suggest that α2A- and α2C-ARs in the DRG may play an important role in generating sympathetically maintained neuropathic pain.

KW - Dorsal root ganglion

KW - Gene expression

KW - In situ hybridization

KW - Neuropathic pain

KW - Reverse transcriptase-polymerase chain reaction

KW - α-adrenergic receptor

UR - https://www.scopus.com/pages/publications/0030768057

U2 - 10.1097/00001756-199709290-00022

DO - 10.1097/00001756-199709290-00022

M3 - Article

C2 - 9331925

AN - SCOPUS:0030768057

SN - 0959-4965

VL - 8

SP - 3119

EP - 3122

JO - NeuroReport

JF - NeuroReport

IS - 14

ER -

Changes in the α₂-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain

Abstract

Keywords

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