Characterization and clinical application of mesenchymal stem cells from equine umbilical cord blood

Jun Gu Kang; Sang Bum Park; Min Soo Seo; Hyung Sik Kim; Joon Seok Chae; Kyung Sun Kang

doi:10.4142/jvs.2013.14.3.367

Characterization and clinical application of mesenchymal stem cells from equine umbilical cord blood

Jun Gu Kang, Sang Bum Park, Min Soo Seo, Hyung Sik Kim, Joon Seok Chae, Kyung Sun Kang

Department of Veterinary Medicine

Seoul National University

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Tendinitis of the superficial digital flexor tendon (SDFT) is a significant cause of lameness in horses; however, recent studies have shown that stem cells could be useful in veterinary regenerative medicine. Therefore, we isolated and characterized equine umbilical cord blood mesenchymal stem cells (eUCB-MSCs) from equine umbilical cord blood obtained from thoroughbred mares during the foaling period. Horses that had tendinitis of the SDFT were treated with eUCB-MSCs to confirm the therapeutic effect. After eUCB-MSCs transplantation, the core lesion in the SDFT was found to decrease. These results suggest that transplantation using eUCB-MSCs could be another source of cell treatment.

Original language	English
Pages (from-to)	367-371
Number of pages	5
Journal	Journal of Veterinary Science
Volume	14
Issue number	3
DOIs	https://doi.org/10.4142/jvs.2013.14.3.367
State	Published - 2013

Keywords

Cell transplantation
Equine
Mesenchymal stem cells
Umbilical cord blood

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title = "Characterization and clinical application of mesenchymal stem cells from equine umbilical cord blood",

abstract = "Tendinitis of the superficial digital flexor tendon (SDFT) is a significant cause of lameness in horses; however, recent studies have shown that stem cells could be useful in veterinary regenerative medicine. Therefore, we isolated and characterized equine umbilical cord blood mesenchymal stem cells (eUCB-MSCs) from equine umbilical cord blood obtained from thoroughbred mares during the foaling period. Horses that had tendinitis of the SDFT were treated with eUCB-MSCs to confirm the therapeutic effect. After eUCB-MSCs transplantation, the core lesion in the SDFT was found to decrease. These results suggest that transplantation using eUCB-MSCs could be another source of cell treatment.",

keywords = "Cell transplantation, Equine, Mesenchymal stem cells, Umbilical cord blood",

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AU - Kang, Jun Gu

AU - Park, Sang Bum

AU - Seo, Min Soo

AU - Kim, Hyung Sik

AU - Chae, Joon Seok

AU - Kang, Kyung Sun

PY - 2013

Y1 - 2013

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AB - Tendinitis of the superficial digital flexor tendon (SDFT) is a significant cause of lameness in horses; however, recent studies have shown that stem cells could be useful in veterinary regenerative medicine. Therefore, we isolated and characterized equine umbilical cord blood mesenchymal stem cells (eUCB-MSCs) from equine umbilical cord blood obtained from thoroughbred mares during the foaling period. Horses that had tendinitis of the SDFT were treated with eUCB-MSCs to confirm the therapeutic effect. After eUCB-MSCs transplantation, the core lesion in the SDFT was found to decrease. These results suggest that transplantation using eUCB-MSCs could be another source of cell treatment.

KW - Cell transplantation

KW - Equine

KW - Mesenchymal stem cells

KW - Umbilical cord blood

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ER -

Characterization and clinical application of mesenchymal stem cells from equine umbilical cord blood

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