Characterization of the cellular localization of C4orf34 as a novel endoplasmic reticulum resident protein

Mi Hee Jun; Young Wu Jun; Kun Hyung Kim; Jin A. Lee; Deok Jin Jang

doi:10.5483/BMBRep.2014.47.10.252

Characterization of the cellular localization of C4orf34 as a novel endoplasmic reticulum resident protein

Mi Hee Jun, Young Wu Jun, Kun Hyung Kim, Jin A. Lee, Deok Jin Jang

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Human genome projects have enabled whole genome mapping and improved our understanding of the genes in humans. However, many unknown genes remain to be functionally characterized. In this study, we characterized human chromosome 4 open reading frame 34 gene (hC4orf34). hC4orf34 was highly conserved from invertebrate to mammalian cells and ubiquitously expressed in the organs of mice, including the heart and brain. Interestingly, hC4orf34 is a novel ER-resident, type I transmembrane protein. Mutant analysis showed that the transmembrane domain (TMD) of hC4orf34 was involved in ER retention. Overall, our results indicate that hC4orf34 is an ER-resident type I transmembrane protein, and might play a role in ER functions including Ca²⁺ homeostasis and ER stress.

Original language	English
Pages (from-to)	563-568
Number of pages	6
Journal	BMB Reports
Volume	47
Issue number	10
DOIs	https://doi.org/10.5483/BMBRep.2014.47.10.252
State	Published - 2014

Keywords

C4orf32
C4orf34
C4orf52
Endoplasmic reticulum
Type I transmembrane protein

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10.5483/BMBRep.2014.47.10.252

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title = "Characterization of the cellular localization of C4orf34 as a novel endoplasmic reticulum resident protein",

abstract = "Human genome projects have enabled whole genome mapping and improved our understanding of the genes in humans. However, many unknown genes remain to be functionally characterized. In this study, we characterized human chromosome 4 open reading frame 34 gene (hC4orf34). hC4orf34 was highly conserved from invertebrate to mammalian cells and ubiquitously expressed in the organs of mice, including the heart and brain. Interestingly, hC4orf34 is a novel ER-resident, type I transmembrane protein. Mutant analysis showed that the transmembrane domain (TMD) of hC4orf34 was involved in ER retention. Overall, our results indicate that hC4orf34 is an ER-resident type I transmembrane protein, and might play a role in ER functions including Ca2+ homeostasis and ER stress.",

keywords = "C4orf32, C4orf34, C4orf52, Endoplasmic reticulum, Type I transmembrane protein",

author = "Jun, {Mi Hee} and Jun, {Young Wu} and Kim, {Kun Hyung} and Lee, {Jin A.} and Jang, {Deok Jin}",

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AU - Jun, Young Wu

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AU - Lee, Jin A.

AU - Jang, Deok Jin

PY - 2014

Y1 - 2014

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AB - Human genome projects have enabled whole genome mapping and improved our understanding of the genes in humans. However, many unknown genes remain to be functionally characterized. In this study, we characterized human chromosome 4 open reading frame 34 gene (hC4orf34). hC4orf34 was highly conserved from invertebrate to mammalian cells and ubiquitously expressed in the organs of mice, including the heart and brain. Interestingly, hC4orf34 is a novel ER-resident, type I transmembrane protein. Mutant analysis showed that the transmembrane domain (TMD) of hC4orf34 was involved in ER retention. Overall, our results indicate that hC4orf34 is an ER-resident type I transmembrane protein, and might play a role in ER functions including Ca2+ homeostasis and ER stress.

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Characterization of the cellular localization of C4orf34 as a novel endoplasmic reticulum resident protein

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