Abstract
A new compound, 4-methoxyl 5-hydroxymethyl benzoic 3-O-β-D- glucopyranoside (1), has been isolated from the leaves and stems of Acer mandshuricum, along with nine known compounds (2-10). Their structures were determined by a variety of spectroscopic analyses. The effect of compounds 1-10 on the function of osteoblastic MC3T3-E1 cells was examined by determining alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization. Compound 1 significantly increased the function of osteoblastic MC3T3-E1 cells; 5.0 μM of 1 increased ALP activity, collagen synthesis, and mineralization of MC3T3-E1 cells to 114.7, 119.5, and 108.2% (P < 0.05) of the basal value, respectively. In addition, compounds 2-10 also potently increased the function of osteoblastic MC3T3-E1 cells.
| Original language | English |
|---|---|
| Pages (from-to) | 929-933 |
| Number of pages | 5 |
| Journal | Bulletin of the Korean Chemical Society |
| Volume | 31 |
| Issue number | 4 |
| DOIs | |
| State | Published - 20 Apr 2010 |
Keywords
- 4-methoxyl 5-hydroxymethyl benzoic 3-O-β-D-glucopyranoside
- Acer mandshuricum
- Aceraceae
- MC3T3-E1 cell
- Osteoblast differentiation
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