TY - JOUR
T1 - Chemical constituents from the bark of phellodendron amurense and their cytotoxic effects on HL-60 human leukemia cells
AU - Li, Wei
AU - Sun, Ya Nan
AU - Yan, Xi Tao
AU - Yang, Seo Young
AU - Choi, Chun Whan
AU - Kim, Eun Ji
AU - Kang, Hee Kyoung
AU - Kim, Young Ho
PY - 2012/12
Y1 - 2012/12
N2 - Phellodendri Cortex, phellodendron bark, has been used as a stomachic for intestinal function control and as an antimicro and anti-inflammatory agent. In this phytochemical study, eight compounds, berberine (1), palmatine (2), syringin (3), (+)-syringaresinol di-O-β-D-glucopyranoside (4), salvadoraside (5), citrusin B (6), osmanthuside H (7), and kelampayoside A (8), were isolated from the bark of Phellodendron amurense. Their structures were elucidated by comparing spectroscopic data with reported values. Compounds 1-8 were evaluated for cytotoxic activity against HL-60 human promyelocyte leukemia cells in vitro. Among them, compounds 1 and 2 reduced the viability of HL-60 cells significantly, with IC50 values of 26.0 and 18.5 μM, respectively.
AB - Phellodendri Cortex, phellodendron bark, has been used as a stomachic for intestinal function control and as an antimicro and anti-inflammatory agent. In this phytochemical study, eight compounds, berberine (1), palmatine (2), syringin (3), (+)-syringaresinol di-O-β-D-glucopyranoside (4), salvadoraside (5), citrusin B (6), osmanthuside H (7), and kelampayoside A (8), were isolated from the bark of Phellodendron amurense. Their structures were elucidated by comparing spectroscopic data with reported values. Compounds 1-8 were evaluated for cytotoxic activity against HL-60 human promyelocyte leukemia cells in vitro. Among them, compounds 1 and 2 reduced the viability of HL-60 cells significantly, with IC50 values of 26.0 and 18.5 μM, respectively.
KW - Cytotoxicity
KW - HL-60 leukemia cells
KW - Phellodendron amurense
KW - Rutaceae
UR - http://www.scopus.com/inward/record.url?scp=84874583155&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84874583155
SN - 1226-3907
VL - 18
SP - 250
EP - 253
JO - Natural Product Sciences
JF - Natural Product Sciences
IS - 4
ER -