Chemical constituents from the root of Polygonum multiflorum and their soluble epoxide hydrolase inhibitory activity

Ya Nan Sun; Wei Li; Jang Hoon Kim; Xi Tao Yan; Ji Eun Kim; Seo Young Yang; Young Ho Kim

doi:10.1007/s12272-014-0520-4

Chemical constituents from the root of Polygonum multiflorum and their soluble epoxide hydrolase inhibitory activity

Ya Nan Sun, Wei Li, Jang Hoon Kim, Xi Tao Yan, Ji Eun Kim, Seo Young Yang, Young Ho Kim

Department of Biology Education

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Fourteen compounds were isolated from a methanol extract of Polygonum multiflorum roots, and their structures were elucidated by comparing spectroscopic data to published spectra. The inhibitory effects of the isolated compounds on soluble epoxide hydrolase (sEH) were then evaluated. Compounds 1-7 inhibited sEH activity potently, with IC50 values ranging from 6.2 ± 0.5 to 48.6 ± 3.1 μM. Moreover, a kinetic analysis of compounds 1-7 revealed that the inhibitory actions of compounds 1, 3 and 4 were non-competitive, whereas those of compounds 2 and 5-7 were mixed-type.

Original language	English
Pages (from-to)	998-1004
Number of pages	7
Journal	Archives of Pharmacal Research
Volume	38
Issue number	6
DOIs	https://doi.org/10.1007/s12272-014-0520-4
State	Published - 21 Nov 2015

Keywords

Anthraquinone
Polygonaceae
Polygonum multiflorum
Soluble epoxide hydrolase
Stilbene glycoside

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10.1007/s12272-014-0520-4

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title = "Chemical constituents from the root of Polygonum multiflorum and their soluble epoxide hydrolase inhibitory activity",

abstract = "Fourteen compounds were isolated from a methanol extract of Polygonum multiflorum roots, and their structures were elucidated by comparing spectroscopic data to published spectra. The inhibitory effects of the isolated compounds on soluble epoxide hydrolase (sEH) were then evaluated. Compounds 1-7 inhibited sEH activity potently, with IC50 values ranging from 6.2 ± 0.5 to 48.6 ± 3.1 μM. Moreover, a kinetic analysis of compounds 1-7 revealed that the inhibitory actions of compounds 1, 3 and 4 were non-competitive, whereas those of compounds 2 and 5-7 were mixed-type.",

keywords = "Anthraquinone, Polygonaceae, Polygonum multiflorum, Soluble epoxide hydrolase, Stilbene glycoside",

author = "Sun, {Ya Nan} and Wei Li and Kim, {Jang Hoon} and Yan, {Xi Tao} and Kim, {Ji Eun} and Yang, {Seo Young} and Kim, {Young Ho}",

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T1 - Chemical constituents from the root of Polygonum multiflorum and their soluble epoxide hydrolase inhibitory activity

AU - Sun, Ya Nan

AU - Li, Wei

AU - Kim, Jang Hoon

AU - Yan, Xi Tao

AU - Kim, Ji Eun

AU - Yang, Seo Young

AU - Kim, Young Ho

PY - 2015/11/21

Y1 - 2015/11/21

N2 - Fourteen compounds were isolated from a methanol extract of Polygonum multiflorum roots, and their structures were elucidated by comparing spectroscopic data to published spectra. The inhibitory effects of the isolated compounds on soluble epoxide hydrolase (sEH) were then evaluated. Compounds 1-7 inhibited sEH activity potently, with IC50 values ranging from 6.2 ± 0.5 to 48.6 ± 3.1 μM. Moreover, a kinetic analysis of compounds 1-7 revealed that the inhibitory actions of compounds 1, 3 and 4 were non-competitive, whereas those of compounds 2 and 5-7 were mixed-type.

AB - Fourteen compounds were isolated from a methanol extract of Polygonum multiflorum roots, and their structures were elucidated by comparing spectroscopic data to published spectra. The inhibitory effects of the isolated compounds on soluble epoxide hydrolase (sEH) were then evaluated. Compounds 1-7 inhibited sEH activity potently, with IC50 values ranging from 6.2 ± 0.5 to 48.6 ± 3.1 μM. Moreover, a kinetic analysis of compounds 1-7 revealed that the inhibitory actions of compounds 1, 3 and 4 were non-competitive, whereas those of compounds 2 and 5-7 were mixed-type.

KW - Anthraquinone

KW - Polygonaceae

KW - Polygonum multiflorum

KW - Soluble epoxide hydrolase

KW - Stilbene glycoside

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SN - 0253-6269

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JO - Archives of Pharmacal Research

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IS - 6

ER -

Chemical constituents from the root of Polygonum multiflorum and their soluble epoxide hydrolase inhibitory activity

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