Chemical constituents of Panax ginseng sprouts cultivated in Vietnam

Hoang Le Tuan Anh; Ngo Viet Duc; Pham Van Cong; Ngo Van Hieu; Nguyen Van Dan; Vu Thi Trang; Do Thi Thu Hien; Do Thanh Tuan; Le Tuan Anh; Jeong Ah Kim

doi:10.1002/vjch.202300181

Chemical constituents of Panax ginseng sprouts cultivated in Vietnam

Hoang Le Tuan Anh, Ngo Viet Duc, Pham Van Cong, Ngo Van Hieu, Nguyen Van Dan, Vu Thi Trang, Do Thi Thu Hien, Do Thanh Tuan, Le Tuan Anh, Jeong Ah Kim

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Eight compounds, including 20(R)-ginsenoside Rg₃ (1), Ginsenoside Rd (2), ginsenosides Rg₂ (3), ginsenosides Re (4), β-sitosterol (5), daucosterol (6), stigmasterol (7), and stigmasterol-3-O-β-glucoside (8) were isolated from the Panax ginseng sprouts cultivated in Vietnam. Their structures were elucidated by ¹H, ¹³C NMR, and MS spectroscopic techniques and compared with the previous publication. In addition, their inhibitory activity on NO production and cytotoxic effects against human embryonic kidney cells (HEK-293A) and human hepatocellular carcinoma (HepG2) were evaluated. This is the first study of the phytochemical investigation of P. ginseng sprouts cultivated in Vietnam and ginseng sprouts also contained the same main active ginsenosides as in the 4–6-year old roots.

Original language	English
Pages (from-to)	165-171
Number of pages	7
Journal	Vietnam Journal of Chemistry
Volume	62
Issue number	2
DOIs	https://doi.org/10.1002/vjch.202300181
State	Published - Apr 2024

Keywords

Panax ginseng sprouts
anti-inflammatory activity
cytotoxic effects

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@article{8cde5130cd664ec98e9d3d5140569676,

title = "Chemical constituents of Panax ginseng sprouts cultivated in Vietnam",

abstract = "Eight compounds, including 20(R)-ginsenoside Rg3 (1), Ginsenoside Rd (2), ginsenosides Rg2 (3), ginsenosides Re (4), β-sitosterol (5), daucosterol (6), stigmasterol (7), and stigmasterol-3-O-β-glucoside (8) were isolated from the Panax ginseng sprouts cultivated in Vietnam. Their structures were elucidated by 1H, 13C NMR, and MS spectroscopic techniques and compared with the previous publication. In addition, their inhibitory activity on NO production and cytotoxic effects against human embryonic kidney cells (HEK-293A) and human hepatocellular carcinoma (HepG2) were evaluated. This is the first study of the phytochemical investigation of P. ginseng sprouts cultivated in Vietnam and ginseng sprouts also contained the same main active ginsenosides as in the 4–6-year old roots.",

keywords = "Panax ginseng sprouts, anti-inflammatory activity, cytotoxic effects",

author = "\{Tuan Anh\}, \{Hoang Le\} and Duc, \{Ngo Viet\} and \{Van Cong\}, Pham and \{Van Hieu\}, Ngo and \{Van Dan\}, Nguyen and Trang, \{Vu Thi\} and Hien, \{Do Thi Thu\} and Tuan, \{Do Thanh\} and Anh, \{Le Tuan\} and Kim, \{Jeong Ah\}",

note = "Publisher Copyright: {\textcopyright} 2024 Vietnam Academy of Science and Technology and Wiley-VCH GmbH.",

year = "2024",

month = apr,

doi = "10.1002/vjch.202300181",

language = "English",

volume = "62",

pages = "165--171",

journal = "Vietnam Journal of Chemistry",

issn = "2572-8288",

publisher = "John Wiley and Sons Inc.",

number = "2",

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TY - JOUR

T1 - Chemical constituents of Panax ginseng sprouts cultivated in Vietnam

AU - Tuan Anh, Hoang Le

AU - Duc, Ngo Viet

AU - Van Cong, Pham

AU - Van Hieu, Ngo

AU - Van Dan, Nguyen

AU - Trang, Vu Thi

AU - Hien, Do Thi Thu

AU - Tuan, Do Thanh

AU - Anh, Le Tuan

AU - Kim, Jeong Ah

PY - 2024/4

Y1 - 2024/4

N2 - Eight compounds, including 20(R)-ginsenoside Rg3 (1), Ginsenoside Rd (2), ginsenosides Rg2 (3), ginsenosides Re (4), β-sitosterol (5), daucosterol (6), stigmasterol (7), and stigmasterol-3-O-β-glucoside (8) were isolated from the Panax ginseng sprouts cultivated in Vietnam. Their structures were elucidated by 1H, 13C NMR, and MS spectroscopic techniques and compared with the previous publication. In addition, their inhibitory activity on NO production and cytotoxic effects against human embryonic kidney cells (HEK-293A) and human hepatocellular carcinoma (HepG2) were evaluated. This is the first study of the phytochemical investigation of P. ginseng sprouts cultivated in Vietnam and ginseng sprouts also contained the same main active ginsenosides as in the 4–6-year old roots.

AB - Eight compounds, including 20(R)-ginsenoside Rg3 (1), Ginsenoside Rd (2), ginsenosides Rg2 (3), ginsenosides Re (4), β-sitosterol (5), daucosterol (6), stigmasterol (7), and stigmasterol-3-O-β-glucoside (8) were isolated from the Panax ginseng sprouts cultivated in Vietnam. Their structures were elucidated by 1H, 13C NMR, and MS spectroscopic techniques and compared with the previous publication. In addition, their inhibitory activity on NO production and cytotoxic effects against human embryonic kidney cells (HEK-293A) and human hepatocellular carcinoma (HepG2) were evaluated. This is the first study of the phytochemical investigation of P. ginseng sprouts cultivated in Vietnam and ginseng sprouts also contained the same main active ginsenosides as in the 4–6-year old roots.

KW - Panax ginseng sprouts

KW - anti-inflammatory activity

KW - cytotoxic effects

UR - https://www.scopus.com/pages/publications/85186606385

U2 - 10.1002/vjch.202300181

DO - 10.1002/vjch.202300181

M3 - Article

AN - SCOPUS:85186606385

SN - 2572-8288

VL - 62

SP - 165

EP - 171

JO - Vietnam Journal of Chemistry

JF - Vietnam Journal of Chemistry

IS - 2

ER -

Chemical constituents of Panax ginseng sprouts cultivated in Vietnam

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Keywords

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