Chemical constituents of Vietnamese mangrove Hibiscus tiliaceus with antioxidant and alpha-glucosidase inhibitory activity

Le Ba Vinh; Nguyen Thi Minh Nguyet; Chu Duc Thanh; Tran Thu Huong; Le Huyen Tram; Nguyen Van Thong; Nguyen Hoang Minh; Nguyen Phuong Thao; Inkyu Hwang; Seo Young Yang; Young Ho Kim

doi:10.1080/14786419.2019.1672065

Chemical constituents of Vietnamese mangrove Hibiscus tiliaceus with antioxidant and alpha-glucosidase inhibitory activity

Le Ba Vinh, Nguyen Thi Minh Nguyet, Chu Duc Thanh, Tran Thu Huong, Le Huyen Tram, Nguyen Van Thong, Nguyen Hoang Minh, Nguyen Phuong Thao, Inkyu Hwang, Seo Young Yang, Young Ho Kim

Department of Biology Education

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Using various chromatographic techniques, a total of 15 compounds, including one novel megastigmane named tiliaceic acid A (1) and 14 known compounds, were isolated from the traditional medicinal Vietnamese mangrove Hibiscus tiliaceus. Their structures were confirmed based on spectroscopic experiments including, UV, 1 D- and 2 D-NMR, HR-ESI-MS, and ECD analysis. The antioxidant and α-glucosidase inhibitory activities of the isolated compounds from H. tiliaceus were evaluated for the first time. Compound 2 showed strong α-glucosidase inhibitory activity with an IC₅₀ of 77.78 ± 1.00 μM compared with the positive control acarbose at 105.71 ± 2.29 μM.

Original language	English
Pages (from-to)	2899-2904
Number of pages	6
Journal	Natural Product Research
Volume	35
Issue number	17
DOIs	https://doi.org/10.1080/14786419.2019.1672065
State	Published - 2021

Keywords

Hibiscus tiliaceus
Malvaceae
antioxidant
megastigmane
α-glucosidase

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10.1080/14786419.2019.1672065

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Vinh, L. B., Nguyet, N. T. M., Thanh, C. D., Huong, T. T., Tram, L. H., Van Thong, N., Minh, N. H., Thao, N. P., Hwang, I., Yang, S. Y., & Kim, Y. H. (2021). Chemical constituents of Vietnamese mangrove Hibiscus tiliaceus with antioxidant and alpha-glucosidase inhibitory activity. Natural Product Research, 35(17), 2899-2904. https://doi.org/10.1080/14786419.2019.1672065

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title = "Chemical constituents of Vietnamese mangrove Hibiscus tiliaceus with antioxidant and alpha-glucosidase inhibitory activity",

abstract = "Using various chromatographic techniques, a total of 15 compounds, including one novel megastigmane named tiliaceic acid A (1) and 14 known compounds, were isolated from the traditional medicinal Vietnamese mangrove Hibiscus tiliaceus. Their structures were confirmed based on spectroscopic experiments including, UV, 1 D- and 2 D-NMR, HR-ESI-MS, and ECD analysis. The antioxidant and α-glucosidase inhibitory activities of the isolated compounds from H. tiliaceus were evaluated for the first time. Compound 2 showed strong α-glucosidase inhibitory activity with an IC50 of 77.78 ± 1.00 μM compared with the positive control acarbose at 105.71 ± 2.29 μM.",

keywords = "Hibiscus tiliaceus, Malvaceae, antioxidant, megastigmane, α-glucosidase",

author = "Vinh, {Le Ba} and Nguyet, {Nguyen Thi Minh} and Thanh, {Chu Duc} and Huong, {Tran Thu} and Tram, {Le Huyen} and {Van Thong}, Nguyen and Minh, {Nguyen Hoang} and Thao, {Nguyen Phuong} and Inkyu Hwang and Yang, {Seo Young} and Kim, {Young Ho}",

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year = "2021",

doi = "10.1080/14786419.2019.1672065",

language = "English",

volume = "35",

pages = "2899--2904",

journal = "Natural Product Research",

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TY - JOUR

T1 - Chemical constituents of Vietnamese mangrove Hibiscus tiliaceus with antioxidant and alpha-glucosidase inhibitory activity

AU - Vinh, Le Ba

AU - Nguyet, Nguyen Thi Minh

AU - Thanh, Chu Duc

AU - Huong, Tran Thu

AU - Tram, Le Huyen

AU - Van Thong, Nguyen

AU - Minh, Nguyen Hoang

AU - Thao, Nguyen Phuong

AU - Hwang, Inkyu

AU - Yang, Seo Young

AU - Kim, Young Ho

PY - 2021

Y1 - 2021

N2 - Using various chromatographic techniques, a total of 15 compounds, including one novel megastigmane named tiliaceic acid A (1) and 14 known compounds, were isolated from the traditional medicinal Vietnamese mangrove Hibiscus tiliaceus. Their structures were confirmed based on spectroscopic experiments including, UV, 1 D- and 2 D-NMR, HR-ESI-MS, and ECD analysis. The antioxidant and α-glucosidase inhibitory activities of the isolated compounds from H. tiliaceus were evaluated for the first time. Compound 2 showed strong α-glucosidase inhibitory activity with an IC50 of 77.78 ± 1.00 μM compared with the positive control acarbose at 105.71 ± 2.29 μM.

AB - Using various chromatographic techniques, a total of 15 compounds, including one novel megastigmane named tiliaceic acid A (1) and 14 known compounds, were isolated from the traditional medicinal Vietnamese mangrove Hibiscus tiliaceus. Their structures were confirmed based on spectroscopic experiments including, UV, 1 D- and 2 D-NMR, HR-ESI-MS, and ECD analysis. The antioxidant and α-glucosidase inhibitory activities of the isolated compounds from H. tiliaceus were evaluated for the first time. Compound 2 showed strong α-glucosidase inhibitory activity with an IC50 of 77.78 ± 1.00 μM compared with the positive control acarbose at 105.71 ± 2.29 μM.

KW - Hibiscus tiliaceus

KW - Malvaceae

KW - antioxidant

KW - megastigmane

KW - α-glucosidase

UR - http://www.scopus.com/inward/record.url?scp=85073931488&partnerID=8YFLogxK

U2 - 10.1080/14786419.2019.1672065

DO - 10.1080/14786419.2019.1672065

M3 - Article

C2 - 31564138

AN - SCOPUS:85073931488

SN - 1478-6419

VL - 35

SP - 2899

EP - 2904

JO - Natural Product Research

JF - Natural Product Research

IS - 17

ER -

Chemical constituents of Vietnamese mangrove Hibiscus tiliaceus with antioxidant and alpha-glucosidase inhibitory activity

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Keywords

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