Chitinase 3-like 1 induces cancer cell migration in solitary fibrous tumors

Myeong Ju Lee; Hyeng Soo Kim; Ju Heon Kim; Won Woo Choi; Sanggyu Lee

doi:10.1016/j.bbrc.2023.04.057

Chitinase 3-like 1 induces cancer cell migration in solitary fibrous tumors

Myeong Ju Lee, Hyeng Soo Kim, Ju Heon Kim, Won Woo Choi, Sanggyu Lee

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

Abstract

Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that is diagnosed through the detection of the NAB2-STAT6 fusion gene. SFT rarely progresses to malignant tumors; however, metastasis is exhibited in approximately 20% of patients with SFT. In this study, we found that chitinase 3-like 1 (CHI3L1), which induces cancer cell migration, was upregulated in NIH-3T3 cells that were transfected with the NAB2-STAT6 fusion gene. Moreover, the expression levels of the migration markers MMP2 and MMP9 were increased and the p-Akt level was also upregulated. In addition, it was observed that when CHI3L1 siRNA was transfected into NAB2-STAT6-transfected cells, cell migration and proliferation were reduced. Therefore, this study demonstrated that CHI3L1 activates Akt signaling to induce cell migration.

Original language	English
Pages (from-to)	142-146
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	663
DOIs	https://doi.org/10.1016/j.bbrc.2023.04.057
State	Published - 30 Jun 2023

Keywords

Cell migration
CHI3L1
NAB2-STAT6
Solitary fibrous tumor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2023.04.057

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title = "Chitinase 3-like 1 induces cancer cell migration in solitary fibrous tumors",

abstract = "Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that is diagnosed through the detection of the NAB2-STAT6 fusion gene. SFT rarely progresses to malignant tumors; however, metastasis is exhibited in approximately 20\% of patients with SFT. In this study, we found that chitinase 3-like 1 (CHI3L1), which induces cancer cell migration, was upregulated in NIH-3T3 cells that were transfected with the NAB2-STAT6 fusion gene. Moreover, the expression levels of the migration markers MMP2 and MMP9 were increased and the p-Akt level was also upregulated. In addition, it was observed that when CHI3L1 siRNA was transfected into NAB2-STAT6-transfected cells, cell migration and proliferation were reduced. Therefore, this study demonstrated that CHI3L1 activates Akt signaling to induce cell migration.",

keywords = "Cell migration, CHI3L1, NAB2-STAT6, Solitary fibrous tumor",

author = "Lee, \{Myeong Ju\} and Kim, \{Hyeng Soo\} and Kim, \{Ju Heon\} and Choi, \{Won Woo\} and Sanggyu Lee",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

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doi = "10.1016/j.bbrc.2023.04.057",

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T1 - Chitinase 3-like 1 induces cancer cell migration in solitary fibrous tumors

AU - Lee, Myeong Ju

AU - Kim, Hyeng Soo

AU - Kim, Ju Heon

AU - Choi, Won Woo

AU - Lee, Sanggyu

PY - 2023/6/30

Y1 - 2023/6/30

N2 - Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that is diagnosed through the detection of the NAB2-STAT6 fusion gene. SFT rarely progresses to malignant tumors; however, metastasis is exhibited in approximately 20% of patients with SFT. In this study, we found that chitinase 3-like 1 (CHI3L1), which induces cancer cell migration, was upregulated in NIH-3T3 cells that were transfected with the NAB2-STAT6 fusion gene. Moreover, the expression levels of the migration markers MMP2 and MMP9 were increased and the p-Akt level was also upregulated. In addition, it was observed that when CHI3L1 siRNA was transfected into NAB2-STAT6-transfected cells, cell migration and proliferation were reduced. Therefore, this study demonstrated that CHI3L1 activates Akt signaling to induce cell migration.

AB - Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that is diagnosed through the detection of the NAB2-STAT6 fusion gene. SFT rarely progresses to malignant tumors; however, metastasis is exhibited in approximately 20% of patients with SFT. In this study, we found that chitinase 3-like 1 (CHI3L1), which induces cancer cell migration, was upregulated in NIH-3T3 cells that were transfected with the NAB2-STAT6 fusion gene. Moreover, the expression levels of the migration markers MMP2 and MMP9 were increased and the p-Akt level was also upregulated. In addition, it was observed that when CHI3L1 siRNA was transfected into NAB2-STAT6-transfected cells, cell migration and proliferation were reduced. Therefore, this study demonstrated that CHI3L1 activates Akt signaling to induce cell migration.

KW - Cell migration

KW - CHI3L1

KW - NAB2-STAT6

KW - Solitary fibrous tumor

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JF - Biochemical and Biophysical Research Communications

ER -

Chitinase 3-like 1 induces cancer cell migration in solitary fibrous tumors

Abstract

Keywords

UN SDGs

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